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Effect of tempol and tempol plus catalase on intra-renal haemodynamics in spontaneously hypertensive stroke-prone (SHSP) and Wistar rats
Ahmeda, Ahmad F; Rae, Mark G; Al Otaibi, Mohammed F; Anweigi, Lamyia M; Johns, Edward J.
Affiliation
  • Ahmeda, Ahmad F; King Saud University. College of Medicine. Department of Physiology. Riyadh. Saudi Arabia
  • Rae, Mark G; University College Cork. Department of Physiology. Cork. Ireland
  • Al Otaibi, Mohammed F; King Saud University. College of Medicine. Department of Physiology. Riyadh. Saudi Arabia
  • Anweigi, Lamyia M; Princess Nourah bint Abdulrahman University. College of Dentistry. Riyadh. Saud Arabia
  • Johns, Edward J; University College Cork. Department of Physiology. Cork. Ireland
J. physiol. biochem ; 73(2): 207-214, mayo 2017. graf
Article in English | IBECS | ID: ibc-168477
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
Vasoconstriction within the renal medulla contributes to the development of hypertension. This study investigated the role of reactive oxygen species (ROS) in regulating renal medullary and cortical blood perfusion (MBP and CBP respectively) in both stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar rats. CBP and MBP were measured using a laser-Doppler flow meter before and after intra-renal infusion of tempol, the superoxide dismutase (SOD) mimetic or tempol plus catalase, the hydrogen peroxide-degrading enzyme. Tempol infusion significantly elevated blood perfusion within the renal medulla (MBP) in both SHRSP (by 43 ± 7%, P < 0.001) and Wistar rats (by 17 ± 2%, P < 0.05) but the magnitude of the increase was significantly greater in the SHRSP (P < 0.01). When the enzyme catalase and tempol were co-infused, MBP was again significantly increased in SHRSP (by 57 ± 6%, P < 0.001) and Wistar rats (by 33 ± 6%, P < 0.001), with a significantly greater increase in perfusion being induced in the SHRSP relative to the Wistar rats (P < 0.01). Notably, this increase was significantly greater than in those animals infused with tempol alone (P < 0.01). These results suggest that ROS plays a proportionally greater role in reducing renal vascular compliance, particularly within the renal medulla, in normotensive and hypertensive animals, with effects being greater in the hypertensive animals. This supports the hypothesis that SHRSP renal vasculature might be subjected to elevated level of oxidative stress relative to normotensive animals (AU)
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Collection: National databases / Spain Database: IBECS Main subject: Renal Circulation / Catalase / Cyclic N-Oxides / Hypertension / Kidney / Antihypertensive Agents / Antioxidants Limits: Animals Language: English Journal: J. physiol. biochem Year: 2017 Document type: Article Institution/Affiliation country: King Saud University/Saudi Arabia / Princess Nourah bint Abdulrahman University/Saud Arabia / University College Cork/Ireland
Search on Google
Collection: National databases / Spain Database: IBECS Main subject: Renal Circulation / Catalase / Cyclic N-Oxides / Hypertension / Kidney / Antihypertensive Agents / Antioxidants Limits: Animals Language: English Journal: J. physiol. biochem Year: 2017 Document type: Article Institution/Affiliation country: King Saud University/Saudi Arabia / Princess Nourah bint Abdulrahman University/Saud Arabia / University College Cork/Ireland
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