Quality of life after whole brain radiotherapy compared with radiosurgery of the tumor bed: results from a randomized trial
Clin. transl. oncol. (Print)
; 20(2): 150-159, feb. 2018. tab, ilus, graf
Article
in English
| IBECS
| ID: ibc-170554
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background. A recent randomized trial (NCT01535209) demonstrated no difference in neurocognitive function between stereotactic radiotherapy of the tumor bed (SRT-TB) and whole brain radiotherapy (WBRT) in patients with resected single brain metastasis. Patients treated with SRT-TB had lower overall survival compared with the WBRT arm. Here, we compared the health-related quality of life (HRQOL) in patients who received WBRT vs. SRT-TB. Methods. A self-reported questionnaire was used to assess HRQOL (EORTC QLQ-C30 with the QLQ-BN20 module) before RT, 2 months after RT, and every 3 months thereafter. HRQOL results are presented as mean scores and compared between groups. Results. Of 59 randomized patients, 37 (64%) were eligible for HRQOL analysis, 15 received SRT-TB, and 22 had WBRT. There were no differences between groups in global health status and main function scales/symptoms (except for drowsiness and appetite loss, which were worse with WBRT 2 months after RT). Global health status decreased 2 and 5 months after RT, but significantly only for SRT-TB (p = 0.025). Physical function decreased significantly 5 months after SRT-TB (p = 0.008). Future uncertainty worsened after RT, but significantly only for SRT-TB after 2 months (p = 0.036). Patients treated with WBRT had significant worsening of appetite, hair loss, and drowsiness after treatment. Conclusions. Despite higher symptom burden after WBRT attributed to the side effects of RT (such as appetite loss, drowsiness, and hair loss), global health status, physical functioning, and future uncertainty favored WBRT compared with SRT-TB. This may be related to the compromised brain tumor control with omission of WBRT (AU)
RESUMEN
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Collection:
National databases
/
Spain
Health context:
SDG3 - Target 3.8 Achieve universal access to health
/
SDG3 - Health and Well-Being
Health problem:
Delivery Arrangements
/
Target 3.8 Achieve universal access to health
Database:
IBECS
Main subject:
Radiotherapy
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Brain Neoplasms
/
Radiosurgery
Type of study:
Controlled clinical trial
Aspects:
Patient-preference
Limits:
Humans
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2018
Document type:
Article
Institution/Affiliation country:
Maria Sklodowska-Curie Memorial Oncology Center/Poland
/
Medical University of Lodz/Poland
/
Military Institute of Medicine/Poland
/
Tomaszów Mazowiecki/Poland
/
Warmian & Mazurian Oncology Centre/Poland