The role of vitamin D in hepatic metastases from colorectal cancer
Clin. transl. oncol. (Print)
; 20(3): 259-273, mar. 2018. ilus
Article
in English
| IBECS
| ID: ibc-171313
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Colorectal cancer (CRC) represents a significant health burden worldwide, comprising approximately 10% of annual cancer cases globally. Hepatic metastases are the most common site of CRC metastasis, and are the leading cause of death in CRC patients. There is strong epidemiologic evidence for an inverse association between vitamin D status and risk of CRC; however, the role of vitamin D in the natural history of liver metastases has not yet been investigated. Several researchers have proposed hallmarks of metastases; crucially, metastases can be blocked by interrupting just one rate-limiting step. Vitamin D status has been implicated in each proposed hallmark of metastasis. The aim of this review is to examine the potential role for vitamin D in reducing the development of hepatic metastases from CRC and outline the candidate mechanisms by which vitamin D may mediate these effects. The results of ongoing randomised intervention trials are eagerly awaited to determine whether addressing vitamin D insufficiency in CRC patients could reduce the occurrence of liver metastases, and the consequent morbidity and mortality (AU)
RESUMEN
No disponible
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Collection:
National databases
/
Spain
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Colon and Rectum Cancers
/
Digestive System Diseases
/
Liver Cancer
/
Malnutrition and Nutritional Deficiencies
Database:
IBECS
Main subject:
Vitamin D
/
Colorectal Neoplasms
/
Liver Neoplasms
Type of study:
Controlled clinical trial
/
Etiology study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2018
Document type:
Article
Institution/Affiliation country:
Alberta Health Services/Canada