Your browser doesn't support javascript.
loading
Mast cell stabilization with ketotifen decreases il-13 and cgrp in the ascitic fluid of rats with microsurgical cholestasis
Aller-Reyero, MA; Tavares, E; Arias, A; Cuervas-Mons, V; Miñano, FJ; Arias, J.
Affiliation
  • Aller-Reyero, MA; Complutense University of Madrid. School of Medicine. Surgery Department. Madrid. Spain
  • Tavares, E; University of Sevilla. Valme Virgen University Hospital. Clinical and Experimental Pharmacology Unit. Sevilla. Spain
  • Arias, A; Autonoma University of Madrid. Puerta de Hierro Hospital. Internal Medicine Department. Madrid. Spain
  • Cuervas-Mons, V; Autonoma University of Madrid. Puerta de Hierro Hospital. Internal Medicine Department. Madrid. Spain
  • Miñano, FJ; University of Sevilla. Valme Virgen University Hospital. Clinical and Experimental Pharmacology Unit. Sevilla. Spain
  • Arias, J; Complutense University of Madrid. School of Medicine. Surgery Department. Madrid. Spain
Rev. esp. investig. quir ; 21(1): 3-7, 2018. graf, tab
Article in English | IBECS | ID: ibc-173354
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
Ascites is one of the most severe complications of cirrhosis with portal hypertension. Since mast cells by type 2 immunity could be involved in the production of portal hypertensive ascites, we are studying the effectiveness of Ketotifen administration, a mast cell stabilizer, to modulate the production of interleukin-13, a type-2 associated cytokine, as well as calcitonin gene-related peptide (CGRP), one important regulator of its production, in the ascitic fluid of microsurgical extrahepatic cholestatic rats. The increased IL-13 and CGRP release in the ascitic fluid of the rats with obstructive cholestasis and its significant reduction after both, prophylactic plus therapeutic and delayed therapeutic oral administration of Ketotifen, allows for proposing that mast cells could play an important role in the etiopathogeny of portal hypertensive ascites
RESUMEN
No disponible
Subject(s)
Fulltext
Add to My VHL
Print
XML
Search on Google
Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Ascitic Fluid / Cholestasis / Ketamine / Microsurgery Limits: Animals Language: English Journal: Rev. esp. investig. quir Year: 2018 Document type: Article Institution/Affiliation country: Autonoma University of Madrid/Spain / Complutense University of Madrid/Spain / University of Sevilla/Spain
Fulltext
Add to My VHL
Print
XML
Search on Google
Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Ascitic Fluid / Cholestasis / Ketamine / Microsurgery Limits: Animals Language: English Journal: Rev. esp. investig. quir Year: 2018 Document type: Article Institution/Affiliation country: Autonoma University of Madrid/Spain / Complutense University of Madrid/Spain / University of Sevilla/Spain