Pathology findings and clinical outcomes after risk reduction salpingo-oophorectomy in BRCA mutation carriers: a multicenter Spanish study
Clin. transl. oncol. (Print)
; 20(10): 1337-1344, oct. 2018. tab, graf
Article
in English
| IBECS
| ID: ibc-173722
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Objective:
To determine the incidence of serous tubal intraepithelial carcinoma (STIC) after risk reduction salpingo-oophorectomy(RRSO), and to describe oncological outcomes after RRSO. Materials andmethods:
BRCA pathogenic mutation carriers who had undergone an RRSO were evaluated in this retrospective multicenter observational study. Patients were only included when fallopian tubes were analyzed following the protocol for Sectioning and Extensively Examining the FIMbria (SEE-FIM). Surgeries were performed between June 2010 and April 2017 at eight Spanish hospitals.Results:
A total of 359 patients met the inclusion criteria. STIC was diagnosed in 3 (0.8%) patients; one of them underwent surgical staging due to positive peritoneal washing, with absence of disease at the final pathology report. None of the three patients received adjuvant chemotherapy and were free of disease at last follow-up. Fallopian tube and ovarian carcinoma were diagnosed in 5 (1.4%) and 1 (0.3%), respectively. At a median (range) follow-up time of 29 (3-92) months, five patients had a newly diagnosed breast cancer. Other types of cancer, which were diagnosed during the follow-up time, included serous primary peritoneal carcinoma (n = 1), serous endometrial carcinoma (n = 1), colon (n = 1), pancreas (n = 1), jaw (n = 1), and lymphoma (n = 1). Seven patients died due to different types of cancer breast (n = 4), pancreas (n = 1), jaw (n = 1), and colon (n = 1).Conclusion:
The incidence of STIC after RRSO in BRCA mutation carriers is low (0.8%) and it presents an excellent oncological outcome. Patients after RRSO, however, run the risk to develop other types of cancer during follow-up and should be properly advised before the prophylactic surgeryRESUMEN
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Collection:
National databases
/
Spain
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
Health problem:
Goal 9: Noncommunicable diseases and mental health
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Target 3.4: Reduce premature mortality due to noncommunicable diseases
Database:
IBECS
Main subject:
Ovarian Neoplasms
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Ovariectomy
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Genes, BRCA1
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Salpingectomy
Type of study:
Controlled clinical trial
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Diagnostic study
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Etiology study
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Practice guideline
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Observational study
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Risk factors
Limits:
Female
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Humans
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2018
Document type:
Article
Institution/Affiliation country:
CEU San Pablo University/Spain
/
Complejo Hospitalario Universitario Insular Materno-Infantil de Canarias (CHUIMI)/Spain
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Hospital Italiano de Buenos Aires/Argentina
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Hospital Universitario 12 de Octubre/Spain
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Hospital Universitario Príncipe de Asturias de Alcalá de Henares/Spain
/
Hospital Universitario Quirón/Spain
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Hospital Universitario Reina Sofía/Spain
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Hospital Universitario Vall d'Hebron/Spain
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Hospital Universitario de Getafe/Spain
/
Instituto Valenciano de Oncología (IVO)/Spain