Concurrent chemoradiation for locally advanced stage III non-small cell lung cancer with cisplatin, vinorelbine, and thoracic radiotherapy: a phase II study from the Galician Lung Cancer Group
Clin. transl. oncol. (Print)
; 20(11): 1467-1473, nov. 2018. ilus, tab, graf
Article
in English
| IBECS
| ID: ibc-173739
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Purpose:
The aim of this phase II study was to evaluate the activity and safety of the combination of cisplatin and vinorelbine with thoracic radiotherapy in unresectable locally advanced stage III non-small cell lung cancer (NSCLC). The primary endpoint was the objective response rate (ORR). Secondary objectives included toxicity profile, progression-free survival (PFS), and overall survival (OS). Materials andmethods:
A total of 48 NSCLC patients were enrolled (median age 60 years, 52% stage IIIA and 48% stage IIIB, 52% adenocarcinoma). Patients received three cycles of chemotherapy every 21 days [intravenous cisplatin 80 mg/m2 and intravenous vinorelbine 25 mg/m2 on day 1 and oral vinorelbine on day 8 (60 mg/m2)] concurrent with radiotherapy (66 Gy, administered at 1.8 Gy per day, five consecutive days per week).Results:
ORR was 79.2% (72.9% showing partial response and 6.3% showing complete response). With a median follow-up of 20.7 months, median PFS was 12 months and median OS was 36 months. Grade 3/4 toxicities were neutropenia (14.5%), anaemia (6.2%), vomiting (2%), and oesophagitis (4.2%). No toxic deaths were reported.Conclusion:
This combined regimen shows efficacy and a manageable safety profile. PFS and OS outcomes are encouraging and warrant further researchRESUMEN
No disponible
Search on Google
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Carcinoma, Non-Small-Cell Lung
/
Chemoradiotherapy
/
Lung Neoplasms
Limits:
Humans
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2018
Document type:
Article
Institution/Affiliation country:
Centro Oncológico de Galicia/Spain
/
Complexo Hospitalario Universitario de Ferrol/Spain
/
Complexo Hospitalario Universitario de Ourense/Spain
/
Complexo Hospitalario Universitario de Santiago de Compostela/Spain
/
Complexo Hospitalario Universitario de Vigo/Spain
/
Complexo Hospitalario de Pontevedra/Spain
/
Hospital Universitario Lucus Augusti de Lugo/Spain