Evaluation of a vancomycin dosing nomogram in obese patients weighing at least 100 kilograms
Pharm. pract. (Granada, Internet)
; 16(3): 0-0, jul.-sept. 2018. tab, graf
Article
in English
| IBECS
| ID: ibc-174798
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background:
There remains variability in both practice and evidence related to optimal initial empiric dosing strategies for vancomycin.Objective:
Our primary objective was to describe the percentage of obese patients receiving vancomycin doses consistent with nomogram recommendations achieving targeted initial steady-state serum vancomycin concentrations. Secondary objectives were to describe the primary endpoint in subgroups based on patient weight and estimated creatinine clearance, to describe the rate of supratherapeutic vancomycin accumulation following an initial therapeutic trough concentration, and to describe the rate of vancomycin-related adverse events.Methods:
This single-center, IRB-approved, retrospective cohort included adult patients ≥ 100 kilograms total body weight with a body mass index (BMI) >30 kilograms/m2 who received a stable nomogram-based vancomycin regimen and had at least one steady-state vancomycin trough concentration. Data collected included vancomycin regimens and concentrations, vancomycin indication, serum creatinine, and vancomycin-related adverse events. Patients were divided into two cohorts by goal trough concentration 10-15 mcg/mL and 15-20 mcg/mL.Results:
Of 325 patients screened, 85 were included. Goal steady-state concentrations were reached in 42/85 (49.4%) of total patients.Conclusions:
Achievement of initial steady-state vancomycin serum concentrations in the present study (approximately 50%) was consistent with the use of published vancomycin dosing nomogramsRESUMEN
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Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Vancomycin
/
Nomograms
/
Dosage Forms
/
Obesity
Type of study:
Practice guideline
/
Observational study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Pharm. pract. (Granada, Internet)
Year:
2018
Document type:
Article
Institution/Affiliation country:
Campbell University/United States