Periodontal treatment on patients with cardiovascular disease: Systematic review and meta-analysis
Med. oral patol. oral cir. bucal (Internet)
; 23(6): e681-e690, nov. 2018. tab, graf
Article
in English
| IBECS
| ID: ibc-176390
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
Atherosclerotic cardiovascular disease is the main cause of mortality in developed countries. It is a chronic and systemic inflammatory disease with a multifactorial etiology. Periodontal disease is one of the many factors that contribute to its development.OBJECTIVE:
To analyze the effects of periodontal treatment on cardiovascular risk parameters in patients with atherosclerotic cardiovascular disease. MATERIAL ANDMETHODS:
A systematic research was conducted in the Pubmed/Medline databases for clinical trials published up to and including the year 2017.RESULTS:
Ten articles were included for analysis. Periodontal treatment reduced C-reactive protein levels (77.8% of clinical trials), tumor necrosis factor-alpha (66.7%), interleukin-6 (100%) and leukocytes (50%). Fibrinogen levels also improved considerably (66.7%). Effects on lipid parameters were more limited, whereby only oxidized low density lipoprotein and very low density lipoprotein cholesterol decreased significantly. Meta-analysis showed a statistically significant decreased in C-reactive protein and leukocytes values when patients were submitted to non-surgical periodontal treatment in contrast to receiving no treatment at all (mean difference 1.199 mg/L, 95% confidence interval 1.100-1.299, p < 0.001; and mean difference 0,79 g/L, 95% confidence interval 0.717-0.879, p < 0.001, respectively).CONCLUSIONS:
Periodontal treatment has a beneficial effect on some of the biochemical parameters considered to represent cardiovascular risk. Further randomized clinical trials are necessary, with longer follow-up periods including regular periodic monitoring, in order to determine the extent of the impact of periodontal treatmentRESUMEN
No disponible
Full text:
Available
Collection:
National databases
/
Spain
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Cardiovascular Disease
/
Oral Conditions and Disorders
Database:
IBECS
Main subject:
Periodontal Diseases
/
Cardiovascular Diseases
Type of study:
Controlled clinical trial
/
Systematic review
Limits:
Humans
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2018
Document type:
Article
Institution/Affiliation country:
University Hospital of Bellvitge/Spain
/
University of Barcelona/Spain