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Prevalence of D. fragilis infection in the household contacts of a group of infected patients / Prevalencia de infección por D. fragilis en contactos domiciliarios de un grupo de pacientes infectados
Menéndez Fernández-Miranda, Candela; Fernández-Suarez, Jonathan; Rodríguez-Pérez, Mercedes; Menéndez Fernández-Miranda, Pablo; Vázquez, Fernando; Boga Ribeiro, Jose A; Rodríguez-Guardado, Azucena.
Affiliation
  • Menéndez Fernández-Miranda, Candela; Hospital Universitario Central de Asturias. Tropical Medicine Unit. Oviedo. Spain
  • Fernández-Suarez, Jonathan; Hospital Universitario Central de Asturias. Microbiology Unit. Oviedo. Spain
  • Rodríguez-Pérez, Mercedes; Hospital Universitario Central de Asturias. Microbiology Unit. Oviedo. Spain
  • Menéndez Fernández-Miranda, Pablo; Hospital Universitario Central de Asturias. Tropical Medicine Unit. Oviedo. Spain
  • Vázquez, Fernando; Hospital Universitario Central de Asturias. Microbiology Unit. Oviedo. Spain
  • Boga Ribeiro, Jose A; Hospital Universitario Central de Asturias. Microbiology Unit. Oviedo. Spain
  • Rodríguez-Guardado, Azucena; Hospital Universitario Central de Asturias. Tropical Medicine Unit. Oviedo. Spain
Enferm. infecc. microbiol. clín. (Ed. impr.) ; 36(7): 423-427, ago.-sept. 2018. graf, tab
Article in English | IBECS | ID: ibc-176723
Responsible library: ES1.1
Localization: BNCS
ABSTRACT

INTRODUCTION:

The results of a study on the household contacts of patients with D. fragilis infection are presented.

METHODS:

A prospective, descriptive study was carried out on all Dientamoeba fragilis-infected patients treated at the Tropical Medicine Unit of Hospital Universitario Central de Asturias between 2012- 2017 and their household contacts. Three stool samples per patient and three stool samples from each of their household contacts were concentrated and analysed. Polymerase chain reaction (PCR) was used to detect the presence of D. fragilis in all stool samples. Co-infection with E. vermicularis was studied in both groups. Patients and contacts who failed to deliver one or more samples for diagnosis and patients without household contacts were excluded.

RESULTS:

44 Patients infected with D. fragilis, as well as their 97 household contacts were enrolled. 50.5% of household contacts had a positive PCR for D. fragilis. 20 were also coinfected with E. vermicularis. The presence of infection was significantly more frequent in patients with children (34/15 versus 24/24; p= 0.064; OR 2.267 [0.988-5.199]), E. vermicularis infection in the children being 20/29 versus 0/48 (p = 0.0001), and in another family member being 29/20 versus 15/33 (p = 0.008; OR 3.190 [1.384-7.352]).

CONCLUSIONS:

The prevalence of D. fragilis infection in household contacts was high. It was associated with the presence of children in the family nucleus and coinfection with E. vermicularis irrespective of gender, age, rural area or contact with animals
RESUMEN

INTRODUCCIÓN:

Los informes de sensibilidad acumulada son una herramienta valiosa para guiar el tratamiento empírico de infecciones urinarias, sobre todo en el contexto actual de crecientes tasas de resistencia. Nuestro objetivo es analizar la sensibilidad antimicrobiana de bacterias aisladas de urocultivos de pacientes pediátricos durante un período de 5 años.

MÉTODOS:

Estudio retrospectivo de los urocultivos del período 2011-2015. La identificación y estudios de sensibilidad se realizaron con el sistema Vitek-2 (BioMérieux(R)) y se interpretaron según los criterios de EUCAST. Se analizaron los datos de sensibilidad antimicrobiana según sexo y tramos de edad (neonatos, 1 mes-5 años, 5-15 años) y se compararon con los datos de mayores de 15 años.

RESULTADOS:

En el período analizado se procesaron 17.164 urocultivos de 7.924 pacientes menores de 16 años. Los porcentajes de sensibilidad en estos pacientes fueron ampicilina 36,3%; amoxicilina/clavulánico 75,3%; cefuroxima 83,2%; cotrimoxazol 68,9%; ciprofloxacino 85,3%; fosfomicina 85,5%; nitrofurantoína 84,4%, y cefalosporinas de tercera generación 89-91%. Aminoglucósidos (>92%) y carbapenemas (95%) mantienen las mayores tasas de sensibilidad. La prevalencia de aislamientos productores de BLEE fue significativamente menor en niños menores de 16 años (1,5% vs. 4,1%). En menores de 16 años, los aislamientos de Escherichia coli procedentes de mujeres fueron significativamente (p < 0,0001) más sensibles a ampicilina (41% vs. 30%) y amoxicilina-clavulánico (82% vs. 72%) que en varones.

CONCLUSIONES:

La elaboración de informes de sensibilidad acumulados desglosados por edad o sexo permite detectar importantes diferencias. En nuestra área, cefuroxima puede considerarse como primera opción de tratamiento empírico en pacientes pediátricos
Subject(s)

Full text: Available Collection: National databases / Spain Health context: SDG3 - Health and Well-Being Health problem: Target 3.3: End transmission of communicable diseases Database: IBECS Main subject: Bacteroides fragilis / Bacteroides Infections / Contact Tracing Type of study: Observational study / Prevalence study / Prognostic study / Risk factors / Screening study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male Language: English Journal: Enferm. infecc. microbiol. clín. (Ed. impr.) Year: 2018 Document type: Article Institution/Affiliation country: Hospital Universitario Central de Asturias/Spain

Full text: Available Collection: National databases / Spain Health context: SDG3 - Health and Well-Being Health problem: Target 3.3: End transmission of communicable diseases Database: IBECS Main subject: Bacteroides fragilis / Bacteroides Infections / Contact Tracing Type of study: Observational study / Prevalence study / Prognostic study / Risk factors / Screening study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male Language: English Journal: Enferm. infecc. microbiol. clín. (Ed. impr.) Year: 2018 Document type: Article Institution/Affiliation country: Hospital Universitario Central de Asturias/Spain
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