EUS-FNA cytological material from pancreatic lesions: the expression of cathepsins and its predictive value of malignancy
Rev. esp. enferm. dig
; 110(7): 446-450, jul. 2018. tab, graf
Article
in English
| IBECS
| ID: ibc-177709
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Aims:
To assess the expression of cathepsins in pancreatic samples obtained by endoscopic ultrasonography and fine needle aspiration (EUS-FNA) and to investigate their relationship with the staging of the pancreatic ductal adenocarcinoma (PDAC).Methods:
We prospectively included patients with solid pancreatic masses, in which EUS-FNA were performed. Cathepsins B, L, S and H expression was determined in FNA samples.Results:
Seventeen FNA were performed. All cytological material was from PDAC. Expression of cathepsins was predominantly low (B 65%, L 23%, S 76%, and H 41%). We found no correlation between the expression levels and the extension of the neoplasm.Conclusion:
Expression of cathepsins in the cytological material of PDAC is diverse but still poor to be useful in the pre-operative diagnosis. There is no correlation between the expression levels of cathepsins and the extension of the PDACRESUMEN
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Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Pancreatic Neoplasms
/
Cathepsins
/
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Limits:
Humans
Language:
English
Journal:
Rev. esp. enferm. dig
Year:
2018
Document type:
Article
Institution/Affiliation country:
Hospital General Universitario de Alicante/Spain