Fluticasone in mild to moderate atopic dermatitis relapse: a randomized controlled trial
Allergol. immunopatol
; 46(4): 378-384, jul.-ago. 2018. tab, graf
Article
in English
| IBECS
| ID: ibc-177869
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
The long-term efficacy of corticosteroids to prevent atopic dermatitis (AD) relapses has partially been addressed in children. This study compared an intermittent dosing regimen of fluticasone propionate (FP) cream 0.05% with its vehicle base in reducing the risk of relapse in children with stabilized AD.METHODS:
A randomized controlled, multicentric, double-blind trial was conducted. Children (2-10 years) with mild/moderate AD (exclusion criteria >30% affected body surface area and/or head) were enrolled into an Open-label Stabilization Phase (OSP) of up to 2 weeks on twice daily FP. Those who achieved treatment success entered the Double-blind Maintenance Phase (DMP). They were randomly allocated to receive FP or vehicle twice-weekly on consecutive days for 16 weeks. The primary study endpoint was relapse rate; time to relapse and severity of disease were also studied. Kaplan-Meier estimates were calculated.RESULTS:
Fifty-four patients (29 girls) entered the OSP (23 mild AD) and 49 (26 girls) continued into the DMP. Mean age was 5.5 (SD 2.8) and 5.1 (SD 2.3) yrs for FP and vehicle groups, respectively. Four patients withdrew from the DMP (two in every group). Patients treated with FP twice weekly had a 2.7 fold lower risk of experiencing a relapse than patients treated with vehicle (relative risk 2.72, SD 1.28; p = 0.034). FP was also superior to vehicle for delaying time to relapse. Both treatment therapies were well tolerated.CONCLUSION:
This long-term study shows that twice weekly FP provides an effective maintenance treatment to control the risk of relapse in children with ADRESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Dermatitis, Atopic
/
Secondary Prevention
/
Fluticasone
/
Anti-Inflammatory Agents
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2018
Document type:
Article
Institution/Affiliation country:
Centro de Atención Primaria de Pobla de Vallbona/Spain
/
Centro de Salud (CS Barrio de la Luz/Spain
/
Centro de Salud (CS) Barrio de la Luz/Spain
/
Centro de Salud Alacuas/Spain
/
Centro de Salud Alzira/Spain
/
Centro de Salud Burjasot II/Spain
/
Centro de Salud El Vedat de Torrent/Spain
/
Centro de Salud Montserrat/Spain
/
Centro de Salud Paiporta/Spain
/
Centro de Salud Picasent/Spain