Clinical and immunological profile of children aged 5-9 years with persistent egg allergy before oral immunotherapy with egg. A multicenter, randomized controlled trial of the Spanish Society of Pediatric Allergy, Asthma and Clinical Immunology (SEICAP)
Allergol. immunopatol
; 46(5): 415-420, sept.-oct. 2018. tab, graf
Article
in English
| IBECS
| ID: ibc-177875
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
In children with egg protein allergy (EA), the probability of overcoming the allergy decreases with age, and the possibility of suffering severe adverse reactions as a consequence of dietetic transgressions results in worsened quality of life. One treatment option in such cases is oral immunotherapy (OIT) with foods.METHODS:
We present a cohort of children with EA scheduled for OIT with pasteurized raw egg white, describing their clinical and allergic characteristics before the start of OIT.RESULTS:
The median age was six years, and 93% of the patients also suffered other allergies (58% asthma and 38.6% allergy to more than two food groups). In the last year, 14.8% had suffered a severe reaction due to dietetic transgression with egg. The median IgE specific of egg white titer was 38.5 kU/l. A double-blind placebo-controlled food challenge with cooked egg white was performed, and if the test proved positive, it was repeated with pasteurized raw egg white. The mean symptoms-provoking dose was 1.26 g and 0.55 g for cooked egg white and raw egg white, respectively. An IgE specific of ovomucoid titer of <2.045 kU/l differentiated those patients that tolerated cooked egg white.CONCLUSIONS:
OIT with egg is regarded as an option in patients with persistent egg allergy. In the previous challenge test, an IgE specific of ovomucoid titer of <2.045 kU/l differentiates those patients that tolerate cooked egg whiteRESUMEN
No disponible
Search on Google
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Egg Hypersensitivity
/
Egg White
Limits:
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2018
Document type:
Article
Institution/Affiliation country:
Carlos Haya Hospital/Spain
/
Cruces Hospital/Spain
/
Fundación Althaia San Juan de Dios Hospital, Sabadell/Spain
/
Gregorio Marañón Hospital/Spain
/
La Paz University Hospital/Spain
/
San Juan de Dios Hospital/Spain
/
Severo Ochoa University Hospital/Spain
/
Valencia University General Hospital/Spain
/
Vall Hebrón Hospital/Spain