Effects of zoledronic acid and dexamethasone on early phases of socket healing after tooth extraction in rats: A preliminary macroscopic and microscopic quantitative study
Med. oral patol. oral cir. bucal (Internet)
; 24(3): e339-e345, mayo 2019. tab, ilus
Article
in English
| IBECS
| ID: ibc-185642
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background:
The exact pathogenesis of medication-related osteonecrosis of the jaw (MRONJ) is still unknown. The aim of this paper was to investigate the effects of zoledronic acid and dexamethasone on the early phases of socket healing in rats subjected to tooth extractions. Material andMethods:
Thirty male Sprague-Dawley rats were divided into 2 groups pharmacologically treated group (T, n = 20) and non-pharmacologically treated group (C, n=10). T group rats received 0.1 mg/Kg of zoledronic acid (ZOL) and 1 mg/Kg of dexamethasone (DEX) three times a week for 10 consecutive weeks. C group rats were infused with vehicle. After 9 weeks from the first infusion, first maxillary molars were extracted in each of the rats. Quantitative macroscopic and microscopic analysis was performed to evaluate socket healing 8 days after extraction.Results:
Pharmacologically treated rats showed significant inhibition of bone remodeling. Connective tissue/al-eolar bone ratio, osteoclast number and woven bone deposition were significantly reduced in group T compared to group C. Conversely, the proportion of necrotic bone was higher in group T compared to group C (0.8% and 0.3%, respectively. P = 0.031). ZOL plus DEX do not cause gross effects on socket healing at a macroscopic level.Conclusions:
Our findings confirmed that exposure to ZOL plus DEX impairs alveolar wound repair. Inhibition of osteoclastic resorption of socket walls after tooth extraction and the inability to dispose of the necrotic bone may be considered the initial steps of MRONJ onsetRESUMEN
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Full text:
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Osteonecrosis
/
Bone Density Conservation Agents
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2019
Document type:
Article
Institution/Affiliation country:
University of Parma/Italy