Oral squamous cell carcinoma of tongue: Histological risk assessment. A pilot study
Med. oral patol. oral cir. bucal (Internet)
; 24(5): e603-e609, sept. 2019. tab
Article
in English
| IBECS
| ID: ibc-185677
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background:
More than 90% of malignant tumors diagnosed in the oral cavity are Oral Squamous Cell Carcinomas (OSCC) whose preferred location is the tongue. Classically, this disease has affected men preferentially, although recent studies suggest that trends are changing and the proportion of women with OSCC is increasing. In addition, the prevalence of oral cancer is also determined by some risk factors as alcohol consumption and to-bacco. Currently, the Tumor, Node, Metastasis (TNM) classification is employed to defined tumor stage and based on this guide specific treatments are established. However, 5-year-survival does not exceed 50% of cases. The objective of this study is to determine whether a histological risk pattern indicative of higher recurrence might be present in T1-T2 tumors located in the anterior two thirds of the tongue. Material andMethods:
Samples from 26 patients with OSCC were analyzed and histological risk pattern of recur-rent and non-recurrent tumors were compared. We have analyzed histological variables described in Anneroth and Brandwein-Gensler classifications. Additionally, we have also examined both clinical variables such as age, sex or comorbidities, as well as habits such as tobacco or alcohol consumption.Results:
We found that sex (male) and keratinization degree (high or moderate) are directly related with OSCC recurrence. In fact, free illness time is lower in men and higher in those cases with minimal or no keratinization.Conclusions:
Based on the variables analyzed, it has not been possible to establish a histological risk pattern that, complementary to the TNM classification, could have a predictive role in these early-stage tongue carcinomasRESUMEN
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Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Mouth Neoplasms
/
Tongue Neoplasms
/
Carcinoma, Squamous Cell
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2019
Document type:
Article
Institution/Affiliation country:
Universidad Autónoma de Madrid/Spain
/
Universidad Rey Juan Carlos (URJC)/Spain
/
Universitary Hospital of La Paz/Spain