Immunological features in pediatric patients with recurrent and severe infection: Identification of Primary Immunodeficiency Diseases in Merida, Venezuela
Allergol. immunopatol
; 47(5): 437-448, sept.-oct. 2019. tab, graf
Article
in English
| IBECS
| ID: ibc-186518
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Introduction and objectives:
Primary immunodeficiency diseases (PIDs) are disorders associated mainly with recurrent and severe infection and an increase in susceptibility to autoimmune conditions and cancer. In Venezuela, PIDs are underdiagnosed and there is usually a delay in their diagnosis. Hence there are no data concerning the frequency and type of PIDs that occur. The aim of this study was to identify and quantify the types of PIDs that occur in Merida, a population within Venezuela. Patients or materials andmethods:
Following an informative program designed to alert local health professionals to the warning signs for PIDs, patients with a history of recurrent infections were referred to the Instituto de Inmunologia Clinica, Universidad de Los Andes. Results andconclusions:
During the three-year period January 2014 to January 2017, thirty-two cases of PIDs were identified in pediatric patients, and 17 different types of PIDs, were identified. Predominantly antibody deficiencies were most frequent (40.6%), followed by immunodeficiencies affecting cellular and humoral immunity (21.8%), congenital defects of phagocyte (18.7%), CID with associated or syndromic features (9.3%), defects in intrinsic and innate immunity (6.4%) and diseases of immune dysregulation (3.2%). These results have important implications not only to the future approach for management of patients in our regions, but add important knowledge concerning PIDs in Latin America and worldwideRESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Immunologic Deficiency Syndromes
/
Infections
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Infant, Newborn
Country/Region as subject:
South America
/
Venezuela
Language:
English
Journal:
Allergol. immunopatol
Year:
2019
Document type:
Article
Institution/Affiliation country:
Instituto Autónomo Hospital Universitario de Los Andes/Venezuela
/
Universidad de Los Andes/Venezuela
/
Universidad de los Andes/Venezuela
/
Virginia Commonwealth University/USA