Low percentages of regulatory T cells in common variable immunodeficiency (CVID) patients with autoimmune diseases and its association with increased numbers of CD4+CD45RO+ T and CD21low B cells
Allergol. immunopatol
; 47(5): 457-466, sept.-oct. 2019. tab, graf
Article
in English
| IBECS
| ID: ibc-186520
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background:
Common variable immunodeficiency (CVID) is a heterogeneous group of primary antibody deficiencies defined by marked reductions in serum IgG, IgA and/or IgM levels and recurrent bacterial infections. Some patients are associated with defects in T cells and regulatory T cells (Tregs), resulting in recurrent viral infections and early-onset autoimmune disease.Methods:
We analyzed whether there is an association between Tregs cells (CD4+CD25+CD127low and CD4+CD25+FoxP3+); memory T cells (CD4+CD45RO+); memory B cells (CD19+CD27-IgD-); and CD21low B cells (CD19+CD38lowCD21low); as well as autoimmune manifestations in 36 patients with CVID (25 women and 11 men, mean age 24 years), all by flow cytometry.Results:
Fourteen patients presented with autoimmune diseases (AI) (39%), including 11 with autoimmune thrombocytopenia (ITP) (31%); two with vitiligo (6%); one with systemic lupus erythematosus (LES) (3%); and one with multiple sclerosis (MS) (3%). CVID patients with AI had a reduced proportion of Tregs (both CD4+CD25+CD127low and FoxP3+ cells) compared with healthy controls. CVID patients with AI had expanded CD21low B cell populations compared with patients who did not have AI. A correlation between increased CD4+CD45RO T cell populations and reduced Tregs was also observed.Conclusions:
Our results showed that 39% of patients with CVID had AI and reduced Tregs populations. Research in this area might provide noteworthy data to better understand immune dysfunction and dysregulation related to CVIDRESUMEN
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Autoimmune Diseases
/
B-Lymphocytes
/
CD4-Positive T-Lymphocytes
/
Common Variable Immunodeficiency
/
T-Lymphocytes, Regulatory
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2019
Document type:
Article
Institution/Affiliation country:
CINVESTAV/México
/
Centro Médico "La Raza"/México
/
Centro Médico Noreste IMSS/México
/
Hospital Civil de Guadalajara "Dr. Juan I. Menchaca"/México
/
Hospital Universitario/México
/
Hospital de Especialidades del Centro Médico Siglo XXI/México
/
Instituto Nacional de Pediatría SSA/México