Impact of select risk factors on treatment outcome in adults with candidemia
Pharm. pract. (Granada, Internet)
; 17(3): 0-0, jul.-sept. 2019. tab, graf
Article
in English
| IBECS
| ID: ibc-188126
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background:
Studies examining relationships between patient-related factors and treatment outcome in patients with candidemia are limited and often based on all-cause mortality.Objective:
Our purpose was to examine the impact of concurrent renal replacement therapy (RRT) and other pre-specified factors on treatment outcome among adults with candidemia.Methods:
This Institutional Review Board (IRB)-approved, single-center, case-cohort study included patients over 18 years of age admitted to Duke University Hospital between Jun 1, 2013 and Jun 1, 2017 with a blood culture positive for Candida spp. Treatment-, patient-, and disease-specific data were collected, and outcome (success/failure) determined 90 days after the index culture. An odds ratio (OR) and 95% confidence interval (95%CI) were calculated for the following during therapy receipt of RRT, fluconazole monotherapy regimen, intensive care unit (ICU) stay, and neutropenia.Results:
Among the 112 encounters (from 110 unique patients) included, treatment failure occurred in 8/112 (7.1%). Demographics were comparable between outcome groups. Among 12 patients receiving concomitant RRT, only 1 patient failed therapy. With regard to treatment failure, no significant differences were observed with RRT (OR, 1.21; 95%CI, 0.14 - 10.75), fluconazole monotherapy regimen (OR, 1.59; 95%CI, 0.3-8.27), ICU stay (OR, 1.43; 95%CI, 0.32-6.29), and neutropenia (0 treatment failures).Conclusions:
Treatment failure, receipt of concomitant RRT, and neutropenia were infrequent in patients undergoing treatment for candidemia. In our cohort, exposure to RRT, a fluconazole monotherapy regimen, ICU stay, or neutropenia during treatment did not impact treatmentoutcome:
RESUMEN
No disponible
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Candida
/
Candidiasis
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Renal Replacement Therapy
/
Candidemia
/
Neutropenia
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Pharm. pract. (Granada, Internet)
Year:
2019
Document type:
Article
Institution/Affiliation country:
Campbell University/United States
/
University of Virginia Medical Center/United States