Gut microbiota of children with atopic dermatitis: Controlled study in the metropolitan region of São Paulo, Brazil
Allergol. immunopatol
; 48(2): 107-115, mar.-abr. 2020. tab
Article
in English
| IBECS
| ID: ibc-191812
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
It is possible that imbalances in the composition of the gut microbiota or the relationship of the microbiota with the host may be implicated in the origin of allergy. Therefore, we studied the intestinal microbiota of children with atopic dermatitis (AD).METHODS:
Cross-sectional study with 81 children aged 5-11; 23 with AD and 58 controls. Surveys were conducted to obtain demographic, socioeconomic and neonatal data. Diagnosis of AD was made based on the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Eubacteria, Bacteroidetes, Firmicutes, B. fragilis, E. coli, Lactobacillus spp., S. aureus, E. faecalis, Salmonella spp., M. smithii, Bifidobacterium spp., C. difficile and C. perfringens were quantified using real-time PCR.RESULTS:
The analysis showed an association between presence of C. difficile (OR 5.88; 95 % CI 1.24; 27.98), greater abundance of bifidobacteria (OR 11.09; 95 % CI 2.14; 57.39) and a lower abundance of lactobacilli (OR 0.07; 95 % CI 0.01; 0.51) in the gut microbiota of children with AD. Counts of Eubacteria (0,05 × 103 and 8.49 × 103), B. fragilis (0.72 × 109 and 4.5 × 109), Lactobacillus spp. (0.02 × 108 and 0.38 × 108), E. coli (0.13 × 109 and 1.52 × 109) and M. smithii (0.02×108 and 0.31 × 108) were lower in children with AD (P < 0.05).CONCLUSIONS:
This study confirmed that children living in the metropolitan area of São Paulo (Brazil) with AD have a different microbiota pattern with higher prevalence of C. difficile, lower abundance of Lactobacillus and greater abundance of bifidobacteria, regardless of socioeconomic statusRESUMEN
No disponible
Search on Google
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Respiratory Tract Diseases
/
Dermatitis, Atopic
/
Gastrointestinal Microbiome
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Allergol. immunopatol
Year:
2020
Document type:
Article
Institution/Affiliation country:
Univeridade Federal da Bahia/Brazil
/
Universidade Federal de São Paulo/Brazil
/
University Center/Brazil