Pro-inflammatory immunological effects of adipose tissue and risk of food allergy in obesity: Focus on immunological mechanisms
Allergol. immunopatol
; 48(3): 306-312, mayo-jun. 2020. ilus
Article
in En
| IBECS
| ID: ibc-192034
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Over the past three decades, the number of obese people has risen steadily. The chronic low-grade inflammatory state and the non-specific activation of the immune system have contributed greatly to the development of obesity-related immunology. Food allergy as a kind of inflammatory disease with abnormal immune response may be associated with obesity. This review begins with the pro-inflammatory immunological effects of adipose tissue in obesity, and explains the possible effects of obesity on food allergy. In short, obesity not only directly causes imbalance of allergic-related immune cells in adipose tissue, but also indirectly causes this consequence through affecting expression of adipocytokines and peroxisome proliferator-activated receptor gamma (PPARγ) in adipose tissue. As a result, circulating levels of pro-inflammatory factors which are partly derived from adipose tissue increase, which might cause intestinal barrier injury. Therefore, obesity may increase the risk of food allergy
RESUMEN
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Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Adipose Tissue
/
Food Hypersensitivity
/
Inflammation
/
Obesity
Limits:
Humans
Language:
En
Journal:
Allergol. immunopatol
Year:
2020
Document type:
Article