Common variable immunodeficiency: epidemiology, pathogenesis, clinical manifestations, diagnosis, classification, and management
J. investig. allergol. clin. immunol
; 30(1): 14-34, 2020. tab, graf
Article
in English
| IBECS
| ID: ibc-194103
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. It is the most frequent symptomatic antibody deficiency, with a wide variety of infectious and noninfectious complications. Numerous studies have demonstrated that immunological and genetic defects are involved in the pathogenesis of CVID. However, in most cases, the genetic background of the disease remains unidentified. This review aims to discuss various aspects of CVID, including epidemiology, pathogenesis, symptoms, diagnosis, classification, and management
RESUMEN
La inmunodeficiencia variable común (CVID) es un trastorno heterogéneo caracterizado por una hipogammaglobulinemia y por una mayor susceptibilidad a infecciones bacterianas recurrentes. Se trata de la inmunodeficiencia humoral sintomática más frecuente y cursa con una extensa variedad de complicaciones infecciosas y no infecciosas. En la patogenia de la CVID están involucrados diferentes defectos inmunológicos y genéticos. Sin embargo, en la mayoría de los casos, el fondo genético de la enfermedad permanece sin identificar. Esta revisión tiene como objetivo discutir diferentes aspectos de la CVID, incluyendo epidemiología, patogenia, síntomas, diagnóstico, clasificaciones y tratamiento de la enfermedad
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Immunoglobulins, Intravenous
/
Common Variable Immunodeficiency
Limits:
Animals
/
Humans
Language:
English
Journal:
J. investig. allergol. clin. immunol
Year:
2020
Document type:
Article
Institution/Affiliation country:
Alborz University of Medical Sciences/Iran
/
Hospital Virgen del Rocío/Spain
/
Iran University of Medical Science/Iran
/
Tehran University of Medical Science/Iran
/
Tehran University of Medical Sciences/Iran