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Smell and taste dysfunction in COVID-19 is associated with younger age in ambulatory settings: a multicenter cross-sectional study
Izquierdo-Domínguez, A; Rojas-Lechuga, MJ; Chiesa-Estomba, C; Calvo-Henríquez, C; Ninchritz-Becerra, E; Soriano-Reixach, M; Poletti-Serafini, D; Maria Villarreal, I; Maza-Solano, JM; Moreno-Luna, R; Villarroel, PP; Mateos-Serrano, B; Agudelo, D; Valcarcel, F; del Cuvillo, A; Santamaría, A; Mariño-Sánchez, F; Aguilar, J; Vergés, P; Inciarte, A; Soriano, A; Mullol, J; Alobid, I.
Affiliation
  • Izquierdo-Domínguez, A; Consorci Sanitari de Terrassa. Department of Allergy. Rubí. Spain
  • Rojas-Lechuga, MJ; Hospital Clinic Barcelona. Department of Otorhinolaryngology. Rhinology Unit & Smell Clinic. Barcelona. Spain
  • Chiesa-Estomba, C; Donostia University Hospital. Department of Otorhinolaryngology. San Sebastian. Spain
  • Calvo-Henríquez, C; Hospital Complex of Santiago de Compostela. Department of Otorhinolaryngology. Santiago de Compostela. Spain
  • Ninchritz-Becerra, E; Donostia University Hospital. Department of Otorhinolaryngology. San Sebastian. Spain
  • Soriano-Reixach, M; Donostia University Hospital. Department of Otorhinolaryngology. San Sebastian. Spain
  • Poletti-Serafini, D; Hospital General Universitario Gregorio Marañón. Department of Otorhinolaryngology. Rhinology Section. Madrid. Spain
  • Maria Villarreal, I; Hospital Universitario de Fuenlabrada. Department of Otorhinolaryngology. Fuenlabrada. Spain
  • Maza-Solano, JM; University Hospital Virgen de la Macarena. Department of Otorhinolaryngology. Rhinology and Skull Base Unit. Seville. Spain
  • Moreno-Luna, R; University Hospital Virgen de la Macarena. Department of Otorhinolaryngology. Rhinology and Skull Base Unit. Seville. Spain
  • Villarroel, PP; Hospital Universitario Virgen de las Nieves. Department of Otorhinolaryngology. Granada. Spain
  • Mateos-Serrano, B; Hospital Universitario La Paz. Department of Otolaryngology. Madrid. Spain
  • Agudelo, D; Hospital de Sant Joan Despí Moisès Broggi. Department of Otorhinolaryngology. Sant Joan Despí. Spain
  • Valcarcel, F; Hospital Universitario de Cruces. Department of Otorhinolaryngology. Rhinology Section. Bilbao. Spain
  • del Cuvillo, A; Servicio Andaluz de Salud. Hospital de Jerez. Rhinology and Asthma Unit. Jerez. Spain
  • Santamaría, A; Hospital Ramón y Cajal. Department of Otorhinolaryngology. Madrid. Spain
  • Mariño-Sánchez, F; Instituto de Investigaciones Biomédicas August Pi I Sunyer (IDIBAPS). Clinical and Experimental Respiratory Immunoallergy. Barcelona. Spain
  • Aguilar, J; Hospital Reina Sofía de Córdoba. Department of Otorhinolaryngology. Córdoba. Spain
  • Vergés, P; Hospital Vall d'Hebron. Department of Otorhinolaryngology. Barcelona. Spain
  • Inciarte, A; Universitat de Barcelona. Hospital Clínic Barcelona. Department of Infectious Diseases. Barcelona. Spain
  • Soriano, A; Universitat de Barcelona. Hospital Clínic Barcelona. Department of Infectious Diseases. Barcelona. Spain
  • Mullol, J; Universitat de Barcelona. Hospital Clinic Barcelona. Department of Otorhinolaryngology. Rhinology Unit & Smell Clinic. Barcelona. Spain
  • Alobid, I; Centro Médico Teknon. Unidad Alergo Rino. Barcelona. Spain
J. investig. allergol. clin. immunol ; 30(5): 346-357, 2020. tab, graf
Article in English | IBECS | ID: ibc-194303
Responsible library: ES1.1
Localization: BNCS
ABSTRACT

BACKGROUND:

Since the initial anecdotal reports of coronavirus disease 2019 (COVID-19) from China, a growing number of studies have reported on smell and/or taste dysfunction (STD).

OBJECTIVE:

The aim of our study was to investigate the frequency and severity of STD in COVID-19 patients and to evaluate the association with demographic characteristics, hospital admission, symptoms, comorbidities, and blood biomarkers.

METHODS:

We performed a multicenter cross-sectional study on patients who were positive for SARS-CoV-2 (n=846) and controls (n=143) from 15 Spanish hospitals. Data on STD were collected prospectively using an in-person survey. The severity of STD was categorized using a visual analog scale. We analyzed time to onset, recovery rate, time to recovery, hospital admission, pneumonia, comorbidities, smoking, and symptoms.

RESULTS:

STD was at least 2-fold more common in COVID-19-positive patients than in controls. COVID-19-positive hospitalized patients were older, with a lower frequency of STD, and recovered earlier than outpatients. Analysis stratified by severity of STD showed that more than half of COVID-19 patients presented severe loss of smell (53.7%) or taste (52.2%); both senses were impaired in >90%. In the multivariate analysis, older age (>60 years), being hospitalized, and increased C-reactive protein were associated with a better sense of smell and/or taste. COVID-19-positive patients reported improvement in smell (45.6%) and taste (46.1%) at the time of the survey; in 90.6% this was within 2 weeks of infection.

CONCLUSION:

STD is a common symptom in COVID-19 and presents mainly in young and nonhospitalized patients. More studies are needed to evaluate follow-up of chemosensory impairment
RESUMEN

INTRODUCCIÓN:

Desde los informes anecdóticos iniciales de China sobre la enfermedad por coronavirus 2019 (COVID-19), ha habido un número creciente de estudios que describen disfunción del olfato y/o del gusto (DOG).

OBJETIVO:

El objetivo fue investigar la frecuencia y la gravedad de la DOG en pacientes con COVID-19 y evaluar su asociación con características demográficas, ingreso hospitalario, síntomas, comorbilidades y biomarcadores sanguíneos.

MÉTODOS:

Estudio transversal multicéntrico en pacientes con SARS-CoV-2 positivo (n=846) y controles (n=143) de 15 hospitales españoles. Los datos de DOG fueron recopilados de manera prospectiva con una encuesta realizada en persona. La gravedad de la DOG se clasificó por escala visual analógica. Se analizaron el tiempo de aparición de DOG, tasa de recuperación, tiempo de recuperación, ingreso hospitalario, diagnóstico de neumonía, comorbilidades, tabaquismo y síntomas.

RESULTADOS:

La DOG fue al menos 2 veces más común en pacientes COVID-19 en comparación con los controles. Los pacientes hospitalizados con COVID-19 eran mayores, presentaban una menor frecuencia de DOG y se recuperaron antes que los pacientes ambulatorios. El análisis estratificado por gravedad de la DOG mostró que más de la mitad de los sujetos con COVID-19 presentaron pérdida severa del olfato (53,7%) o del gusto (52,2%), en> 90% este deterioro fue de ambos sentidos. En el análisis multivariante, una edad mayor (>60 años), ser hospitalizado y un mayor nivel de proteína C reactiva fueron factores asociados con un mejor sentido del olfato y/o sabor. Los pacientes positivos para COVID-19 informaron una mejoría del olfato (45,6%) y del gusto (46,1%) en el momento de la encuesta, de ellos, un 90,6% en menos de dos semanas después de la infección.

CONCLUSIÓN:

DOG es un síntoma común en COVID-19, y principalmente presente en pacientes jóvenes y no hospitalizados. Se necesitan más estudios para evaluar el seguimiento de la discapacidad quimio-sensorial
Subject(s)

Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Pneumonia, Viral / Taste Disorders / Coronavirus Infections / Ageusia / Olfaction Disorders Limits: Adult / Aged / Female / Humans / Male Language: English Journal: J. investig. allergol. clin. immunol Year: 2020 Document type: Article Institution/Affiliation country: Centro Médico Teknon/Spain / Consorci Sanitari de Terrassa/Spain / Donostia University Hospital/Spain / Hospital Clinic Barcelona/Spain / Hospital Complex of Santiago de Compostela/Spain / Hospital General Universitario Gregorio Marañón/Spain / Hospital Ramón y Cajal/Spain / Hospital Reina Sofía de Córdoba/Spain / Hospital Universitario La Paz/Spain / Hospital Universitario Virgen de las Nieves/Spain

Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Pneumonia, Viral / Taste Disorders / Coronavirus Infections / Ageusia / Olfaction Disorders Limits: Adult / Aged / Female / Humans / Male Language: English Journal: J. investig. allergol. clin. immunol Year: 2020 Document type: Article Institution/Affiliation country: Centro Médico Teknon/Spain / Consorci Sanitari de Terrassa/Spain / Donostia University Hospital/Spain / Hospital Clinic Barcelona/Spain / Hospital Complex of Santiago de Compostela/Spain / Hospital General Universitario Gregorio Marañón/Spain / Hospital Ramón y Cajal/Spain / Hospital Reina Sofía de Córdoba/Spain / Hospital Universitario La Paz/Spain / Hospital Universitario Virgen de las Nieves/Spain
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