Insulinoma masquerading as neurologic disease - Case report and review of the literature
Galicia clin
; 81(2): 54-56, abr. 2020. ilus, tab
Article
in English
| IBECS
| ID: ibc-195199
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Insulinomas are the most frequent etiology of hypoglycemia in a non-diabetic patient and the most common functional neuroendocrine tumors of the pancreas, with an annual incidence of about 4 cases per million. The majority of insulinomas are "well-differentiated endocrine tumors" or grade 1 tumors, as defined by World Health Organization. Most tumors are benign, solitary and occur sporadically. However, about 10% are associated with multiple endocrine neoplasia type 1 (MEN-1). Despite the majority being benign tumors, hypoglycemic symptoms caused by the hyperinsulinemia are frequently debilitating. Whipple triad (hypoglycemia, symptoms of hypoglycemia - either adrenergic or neuroglycopenic - and relief of these symptoms after administration of glucose) is usually present and should alert to the diagnosis.After the diagnosis is made, locating the tumor can be challenging because most tumors are small. Nonetheless, locating the tumor is crucial, once the only definite treatment is surgical excision. The majority of patients reach normalization of glucose levels after surgery. Incomplete resection leads to persistent symptoms and although uncommon in sporadic insulinomas, recurrence can be as high as 20% in patients with MEN-1 syndrome
RESUMEN
No disponible
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Neuroendocrine Tumors
/
Hypoglycemia
/
Insulinoma
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Galicia clin
Year:
2020
Document type:
Article
Institution/Affiliation country:
Espinho+Portugal