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Immunohistochemical and morphological characteristics of tissues response to polylactic acid membranes with silver nanoparticles
Demyashkin, Grigory; Kogan, Eugenia; Borozdkin, Leonid; Demura, Tatyana; Shalamova, Elena; Centroev, Zelimhan; Ivanova, Irina; Gevandova, Margarita; Smirnova-Sotmari, Vlada; Kalinin, Sergey.
Affiliation
  • Demyashkin, Grigory; Sechenov University. Department of Pathology. Moscow. Russia
  • Kogan, Eugenia; European Association of Pathologists. España
  • Borozdkin, Leonid; Sechenov University. Maxillofacial Surgery Department. Moscow. Russia
  • Demura, Tatyana; Sechenov University. Department of Pathology. Moscow. Russia
  • Shalamova, Elena; Sechenov University. Student at International School "Medicine of the Future". Moscow. Russia
  • Centroev, Zelimhan; Sechenov University. Maxillofacial Surgery Department. Moscow. Russia
  • Ivanova, Irina; Sechenov University. Maxillofacial Surgery Department. Moscow. Russia
  • Gevandova, Margarita; Stavropol State Medial University. Department of Biology. Stavropol. Russia
  • Smirnova-Sotmari, Vlada; Sechenov University. Department of Pathology. Moscow. Russia
  • Kalinin, Sergey; Sechenov University. Department of Pathology. Moscow. Russia
Med. oral patol. oral cir. bucal (Internet) ; 25(1): e29-e33, ene. 2020. ilus
Article in English | IBECS | ID: ibc-196193
Responsible library: ES1.1
Localization: BNCS
ABSTRACT

BACKGROUND:

The aim of this research was to study anti-microbial and anti-inflammatory characteristics of silver nanoparticles helping bone structures to recover during late stage of parodontitis, which afterwards will increase the effect of bone regeneration operations. MATERIAL AND

METHODS:

We assessed colloid solution-derived silver nanoparticles coating of polylactic acid membrane regarding tissue foreign body response. Thirty eight polylactic acid membranes were implanted intracranially in rabbits ten unmodified (control group) and twenty eight with silver nanoparticles coating (experimental group). In controls, penicillin was used for infection prophylaxis. Tissue response was assessed by light microscopy and immunohistochemistry (CD3, CD15, CD30) 2 weeks after implantation.

RESULTS:

inflammation markers in experimental group were significantly lower than in control group, there were no signs of forming a fibrosis capsule nor infectious signs.

CONCLUSIONS:

colloid silver solution can be used as a source of nanoparticles for anti-microbial and antiinflammatory biodegradable membranes' coating
RESUMEN
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Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Polyesters / Silver / Metal Nanoparticles / Anti-Infective Agents / Anti-Inflammatory Agents / Occipital Bone Limits: Animals Language: English Journal: Med. oral patol. oral cir. bucal (Internet) Year: 2020 Document type: Article Institution/Affiliation country: European Association of Pathologists/España / Sechenov University/Russia / Stavropol State Medial University/Russia
Fulltext
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Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Polyesters / Silver / Metal Nanoparticles / Anti-Infective Agents / Anti-Inflammatory Agents / Occipital Bone Limits: Animals Language: English Journal: Med. oral patol. oral cir. bucal (Internet) Year: 2020 Document type: Article Institution/Affiliation country: European Association of Pathologists/España / Sechenov University/Russia / Stavropol State Medial University/Russia