CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma
Med. oral patol. oral cir. bucal (Internet)
; 25(1): e49-e55, ene. 2020. ilus, tab, graf
Article
in English
| IBECS
| ID: ibc-196195
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
The objective of this study investigated the distribution of immature dendritic cells (DCs), Langer-hans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). MATERIAL ANDMETHODS:
Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL ̧ 45 of OSCC and 8 of normal epi-thelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified.RESULTS:
A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium.CONCLUSION:
The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformationRESUMEN
No disponible
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Oral Submucous Fibrosis
/
Dendritic Cells
/
Leukoplakia, Oral
/
Mouth Neoplasms
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Carcinoma, Squamous Cell
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2020
Document type:
Article
Institution/Affiliation country:
A. C. Camargo Cancer Center/Brazil
/
Manipal Academy of Higher Education/India
/
Sudha Rustagi College of Dental Sciences and Research/Inida
/
University of Campinas/Brazil
/
University of Minas Gerais/Brazil