Oral Human Papillomavirus: a multisite infection
Med. oral patol. oral cir. bucal (Internet)
; 25(3): e425-e430, mayo 2020. tab
Article
in English
| IBECS
| ID: ibc-196332
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
The Human Papillomavirus (HPV) has different strategies for persist in the cells. This characteristic has led us to consider the presence of the virus in tissues of the oral cavity that had no clinical signs of infection. The aim of this study was to detect the presence of DNA-HPV at multiple sites of the oral cavity. MATERIAL ANDMETHODS:
A case-control study was designed Oral Squamous Carcinoma Group (OSCG), healthy n=72 and Control Group (CG), n=72, healthy volunteers paired by sex and age with OSCG. Four samples were taken from OSCG saliva, biopsy, brush scraping of lesion and contralateral healthy side. In CG a saliva sample and a scratch of the posterior border of tongue were collected. HPV was detected by PCR using Bioneer Accuprep genomic DNA Extraction kit, and consensus primers MY09 and MY11. Chi square test was applied.RESULTS:
432 samples were obtained from 144 individuals. DNA-HPV was detected in 30 (42%) of OSCG subjects and 3 (4%) of CG. Two or more positive samples were obtained in 67% of the OSCG, 67% in saliva and 60% in biopsy; in CG 100% of the individuals were positive in the two samples.CONCLUSIONS:
HPV is frequently present in oral cavity as a multifocal infection, even without the presence of clinical lesionsRESUMEN
No disponible
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Papillomaviridae
/
DNA, Viral
/
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Papillomavirus Infections
/
Mouth
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2020
Document type:
Article
Institution/Affiliation country:
Universidad Nacional de Córdoba/Argentina