Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin - An experimental study in rats
Med. oral patol. oral cir. bucal (Internet)
; 25(4): e532-e540, jul. 2020. ilus, graf, tab
Article
in English
| IBECS
| ID: ibc-196507
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
The aim of this histomorphometric study was to assess the bone regeneration potential of beta-tricalcium phosphate with fibronectin (Beta-TCP-Fn) in critical-sized defects (CSDs) in rats calvarial, to know whether Fn improves the new bone formation in a short time scope. MATERIAL ANDMETHODS:
CSDs were created in 30 Sprague Dawley rats, and divided into four groups (2 or 6 weeks of healing) and type of filling (Beta-TCP-Fn, Beta-TCP, empty control). Variables studied were augmented area (AA), gained tissue (GT), mineralized/non mineralized bone matrix (MBM/NMT) and bone substitute (BS).RESULTS:
60 samples at 2 and six weeks were evaluated. AA was higher for treatment groups comparing to controls (p < 0.001) and significant decrease in BS area in the Beta-TCP-Fn group from 2 to 6 weeks (p = 0.031). GT was higher in the Beta-TCP-Fn group than in the controls expressed in % (p = 0.028) and in mm2 (p = 0.011), specially at two weeks (p=0.056).CONCLUSIONS:
Both Beta-TCP biomaterials are effective as compared with bone defects left empty in maintaining the volume. GT in defects regeneration filed with Beta-TCP-Fn are significantly better in short healing time when comparing with controls but not for Beta-TCP used alone in rats calvarial CSDsRESUMEN
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Full text:
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Bone Regeneration
/
Calcium Phosphates
/
Fibronectins
/
Bone Substitutes
/
Guided Tissue Regeneration
Limits:
Animals
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2020
Document type:
Article
Institution/Affiliation country:
University of Barcelona/Spain
/
University of Santiago de Compostela/Spain