Use of micafungin as antifungal prophylaxis in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) in Spain (GETH-MIC) / Profilaxis antifúngica con micafungina en pacientes que reciben un trasplante alogénico de progenitores hematopoyéticos (alo-TPH) en España (GETH-MIC)
Rev. esp. quimioter
; 33(2): 110-115, abr. 2020. tab, graf
Article
in English
| IBECS
| ID: ibc-197712
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
INTRODUCTION:
The fungal infections remain an important problem in the allogeneic stem cell trasnsplantation (allo-SCT) setting and thus, anti-fungal prophylaxis is commonly used. The antifungal drug should offer activity, at least against Candida and Aspergillus spp., a good safety profile and low probability interactions. Micafungin could theoretically fulfill these requisites. The aim of the study was to describe the experience with micafungin as primary prophylaxis in patients undergoing allo-SCT in a cohort of Spanish centres, and to evaluate its efficacy and tolerability in this population. MATERIAL ANDMETHODS:
Retrospective multicentre observational study including all consecutive adult patients admitted for allo-SCT in participating centres of the Grupo Español de Trasplante Hematopoyético (GETH), from January 2010 to December 2013, who received micafungin as primary prophylaxis during the neutropenic period.RESULTS:
A total of 240 patients from 13 centres were identified and 159 patients were included for the analysis. Most patients (95.6%) received 50 mg/day of micafungin. During the follow-up, 7 (4.4%) patients developed breakthrough invasive fungal disease, 1 proven and 6 probable; one patient discontinued the drug because of serious drug interactions. Prophylaxis with micafungin was considered effective in 151 (94.9%) patiens.CONCLUSIONS:
According to our experience, micafungin is an appropriate alternative for antifungal prophylaxis in patients undergoing an allo-HSCT, because its efficacy, its low profile of drug interactions and side-effects
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Hematopoietic Stem Cell Transplantation
/
Micafungin
/
Mycoses
/
Antifungal Agents
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
English
Journal:
Rev. esp. quimioter
Year:
2020
Document type:
Article
Institution/Affiliation country:
Hospital Clínico Universitario de Valencia/Spain
/
Hospital Jerez de la Frontera/Spain
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Hospital Universitari Vall d'Hebron/Spain
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Hospital Universitario Gregorio Marañón/Spain
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Hospital Universitario Ramón y Cajal/Spain
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Hospital Universitario de La Princesa/Spain
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Hospital Universitario de Salamanca/Spain