Periodontitis and alzheimer's disease
Med. oral patol. oral cir. bucal (Internet)
; 26(1): e43-e48, ene. 2021. ilus, graf
Article
in English
| IBECS
| ID: ibc-200537
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
Alzheimer's disease (AD), the main cause of dementia in the adult population, is characterized by a progressive loss of cognitive function. It is considered that neuroinflammation plays a fundamental role in its onset and progression. The bacteria present in the disbiotic microbiome generated during the course of periodontitis (PE) are capable of inducing a systemic inflammatory response, exacerbating the production of proinflammatory mediators that have the potential to spread to the systemic circulation. MATERIAL ANDMETHODS:
A literature review was made using the databases Scielo, PubMed, EBSCO and key words "Alzheimer disease", "Periodontitis", "Neurodegeneration", "Inflammation mediators", "Elderly".RESULTS:
Several hypotheses point to similar pathophysiological pathways in the establishment of AD and PE, sharing cellular and molecular proinflammatory characteristics. In periodontitis, locally produced cytokines and pro-inflammatory products spread from the ulcerated periodontal pocket into the systemic circulation, or around the trigeminal nerve terminals, which allows the passage of bacteria or their products to the brain. This fact leads to the formation of plaques of amyloid peptide and intraneuronal neurofibrillar tangles (NFTs) that activate the glial cells producing a significant increase in proinflammatory cytokines in the affected regions that lead to a loss of neuronal synapses and neurodegeneration, contributing to the progression of AD.CONCLUSIONS:
This review of the literature contributes to the understanding of the pathological pathways shared by both diseases such as oxidative damage and inflammation. There is not enough evidence to determine an association between this two pathologies, so it is considered necessary to conduct studies for determine if periodontitis is capable of inducing or exacerbating the neuroinflammation that will trigger ADRESUMEN
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Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Periodontitis
/
Alzheimer Disease
/
Inflammation
Limits:
Aged
/
Humans
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2021
Document type:
Article
Institution/Affiliation country:
Autonomous University of Yucatan/México
/
University of Chile/Chile