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Inhibitory effect of polyphenols (phenolic acids, lignans, and stilbenes) on cancer by regulating signal transduction pathways: a review
Hazafa, Abu; Iqbal, M. O.; Javaid, U; Tareen, M. B. K.; Amna, D; Ramzan, A; Piracha, S; Naeem, M.
Affiliation
  • Hazafa, Abu; University of Agriculture. Faculty of Sciences. Faisalabad. Pakistan
  • Iqbal, M. O.; Ocean University of China. Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering. Qingdao. China
  • Javaid, U; Bahauddin Zakariya University. Faculty of Pharmacy. Multan. Pakistan
  • Tareen, M. B. K.; Huazhong Agricultural University. College of Food Science & Technology. Huazhong. China
  • Amna, D; Bahauddin Zakariya University. Multan. Pakistan
  • Ramzan, A; University of Agriculture Faisalabad. Faisalabad. Pakistan
  • Piracha, S; University of Agriculture Faisalabad. Faisalabad. Pakistan
  • Naeem, M; Hebei Normal University. Shijiazhuang. China
Clin. transl. oncol. (Print) ; 24(3): 432-445, marzo 2022.
Article in English | IBECS | ID: ibc-203539
Responsible library: ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Natural products, especially polyphenols (phenolic acids, lignans, and stilbenes) are suggested to be more potent anticancer drugs because of their no or less adverse effects, excess availability, high accuracy, and secure mode of action. In the present review, potential anticancer mechanisms of action of some polyphenols including phenolic acids, lignans, and stilbenes are discussed based on clinical, epidemiological, in vivo, and in vitro studies. The emerging evidence revealed that phenolic acids, lignans, and stilbenes induced apoptosis in the treatment of breast (MCF-7), colon (Caco-2), lung (SKLU-1), prostate (DU-145 and LNCaP), hepatocellular (hepG-2), and cervical (A-431) cancer cells, cell cycle arrest (S/G2/M/G1-phases) in gastric (MKN-45 and MKN-74), colorectal (HCT-116), bladder (T-24 and 5637), oral (H-400), leukemic (HL-60 and MOLT-4) and colon (Caco-2) cancer cells, and inhibit cell proliferation against the prostate (PC-3), liver (LI-90), breast (T47D and MDA-MB-231), colon (HT-29 and Caco-2), cervical (HTB-35), and MIC-1 cancer cells through caspase-3, MAPK, AMPK, Akt, NF-κB, Wnt, CD95, and SIRT1 pathways. Based on accumulated data, we suggested that polyphenols could be considered as a viable therapeutic option in the treatment of cancer cells in the near future.
Subject(s)


Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Stilbenes / Lignans / Hydroxybenzoates Language: English Journal: Clin. transl. oncol. (Print) Year: 2022 Document type: Article Institution/Affiliation country: Bahauddin Zakariya University/Pakistan / Hebei Normal University/China / Huazhong Agricultural University/China / Ocean University of China/China / University of Agriculture Faisalabad/Pakistan / University of Agriculture/Pakistan

Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Stilbenes / Lignans / Hydroxybenzoates Language: English Journal: Clin. transl. oncol. (Print) Year: 2022 Document type: Article Institution/Affiliation country: Bahauddin Zakariya University/Pakistan / Hebei Normal University/China / Huazhong Agricultural University/China / Ocean University of China/China / University of Agriculture Faisalabad/Pakistan / University of Agriculture/Pakistan
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