Traditional Chinese medicine reverses cancer multidrug resistance and its mechanism
Clin. transl. oncol. (Print)
; 24(3): 471-482, marzo 2022.
Article
in English
| IBECS
| ID: ibc-203542
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Chemotherapy is one of the most commonly used clinical treatments among the currently available cancer therapies. However, the phenomenon of Multidrug resistance (MDR) has become a challenge in the treatment process, weakening the impact of chemotherapy. Extensive research on elucidating the development of cancer MDR has identified the following mechanisms that play a critical role in the development of several MDR reversal agents abnormal expression of cell membrane transporters, adaptation of cancer cells to the microenvironment, regulation of hypoxia, repair of DNA damage and reduction of apoptosis, the enhancement of the EMT process, the existence of cancer stem cells (CSCs), and the abnormal activation of key signaling pathways. However, they failed to demonstrate significant efficacy due to severe side effects during their clinical trials. Traditional Chinese medicines (TCMs) are known to play an important anti-cancer role since they have low toxicity, high efficacy, and safety and can reverse MDR. TCMs reversal agents can be divided into Chinese medicine monomers, synthetic monomers, analogs, or derivatives. Several studies have shown that TCMs can effectively overcome cancer MDR and can be effectively used for treating cancer patients.
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Drug Resistance
/
Medicine, Chinese Traditional
/
Neoplasms
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2022
Document type:
Article
Institution/Affiliation country:
China-Japan Union Hospital of Jilin University/China
/
College of Animal Sciences/Peoples Republic of China
/
Guangdong Provincial Hospital of Chinese Medicine-Zhuhai Hospital/China
/
Jilin University/Peoples Republic of China