Diagnostic panel of serum miR-125b-5p, miR-182-5p, and miR-200c-3p as non-invasive biomarkers for urothelial bladder cancer
Clin. transl. oncol. (Print)
; 24(5): 909-918, mayo 2022.
Article
in En
| IBECS
| ID: ibc-203793
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
PurposeThis study aimed to identify a diagnostic panel of serum microRNAs (miRNAs) for the early detection of bladder cancer (BC).MethodsSerum samples were collected from 112 BC patients and 112 normal controls (NCs). A three-stage selection was conducted to identify differentially expressed miRNAs as candidates to construct the diagnostic panel. Further, to explore their potential roles in urothelial BC, bioinformatics analyses, including target genes prediction and functional annotation, were used.ResultsSix downregulated miRNAs (miR-1-3p, miR-30a-5p, miR-100-5p, miR-125b-5p, miR-143-3p, and miR-200c-3p) and one upregulated, miR-182-5p, in BC patients serum were detected compared to NCs and were selected to establish the diagnostic panel. Based on a backward stepwise logistic regression analysis, miR-125b-5p, miR-182-5p, and miR-200c-3p comprehended the diagnostic panel [area under the curve (AUC) = 0.959, sensitivity = 91.67%, specificity = 92.5%].ConclusionThe panel of three miRNAs had an excellent diagnostic capability, representing a potential non-invasive method for early BC detection.
Key words
Full text:
1
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Urinary Bladder Neoplasms
/
Carcinoma, Transitional Cell
/
Biomarkers, Tumor
/
MicroRNAs
Limits:
Humans
Language:
En
Journal:
Clin. transl. oncol. (Print)
Year:
2022
Document type:
Article