Auditory and visual P300 event-related potentials to detect minimal hepatic encephalopathy
Rev. esp. enferm. dig
; 114(2): 83-88, febrero 2022. graf, tab
Article
in English
| IBECS
| ID: ibc-205548
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Introduction:
the diagnosis of minimal hepatic encephalopathy (MHE) requires psychometric tests, although new methods are needed since their sensitivity, specificity, and accuracy are low. The P300 event-related potential (ERP) is obtained by auditory and visual stimuli, although only the auditory P300 has been used to detect MHE. This study aimed to compare the diagnostic features of auditory and visual P300 to detect MHE.Materials andmethods:
sixty patients with liver cirrhosis and thirty-five healthy controls completed the Psychometric Hepatic Encephalopathy Score (PHES), the critical flicker frequency (CFF), and auditory and visual P300 tests. MHE was diagnosed if PHES and CFF scores were abnormal.Results:
fifty-three cirrhotic patients (aged 54.5 ± 8.6 years) completed all tests. Abnormal scores were obtained for PHES (49.1 %) and CFF (67.9 %). The proportion of MHE was 21.4 %. The area under the receiver operating (ROC) curves (AUROC) for auditory P300 was better than for visual P300 for distinguishing MHE from controls (AUROC 0.792 vs 0.725; p < 0.005 for both; accuracy 73.8 % vs 70.2 %; sensitivity 72.2 % for both; specificity 74.2 vs 69.7, respectively). Among cirrhotic patients, only auditory P300 was useful to detect MHE (AUROC 0.723; p < 0.05; 77.4 % accuracy; 61.1 % sensitivity, and 81.8 % specificity).Conclusions:
auditory P300 sensitivity, specificity, and accuracy were similar to those of CFF. Our results showed that only auditory P300 is useful to differentiate patients with MHE, although both modalities, auditory and visual, differentiated patients with cirrhosis from controls. Thus, we consider that visual P300 is not suitable for detecting MHE. (AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Hepatic Encephalopathy
/
Event-Related Potentials, P300
/
Liver Cirrhosis
Limits:
Humans
Language:
English
Journal:
Rev. esp. enferm. dig
Year:
2022
Document type:
Article
Institution/Affiliation country:
Hospital General de México Dr. Eduardo Liceaga/Mexico