Participation in clinical trials increases the detection of pre-malignant lesions during colonoscopy
Rev. esp. enferm. dig
; 114(6): 323-328, junio 2022. tab
Article
in English
| IBECS
| ID: ibc-205651
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
RESUMEN
Background:
colorectal adenoma detection has been associated with the effectiveness of cancer prevention. Clinical trials have been designed to determine the role of several interventions to increase the detection of pre-malignant lesions. We hypothesized that colonoscopy in the setting of clinical trials has a higher pre-malignant lesion detection rate.Methods:
a cross-sectional study was performed that compared the detection of pre-malignant lesions in 147 randomly sampled non-research colonoscopies and 294 from the control group of two prospective trials. Outpatients aged 40-79 years, with no personal history of colorectal cancer (CRC) were included.Results:
baseline characteristics were similar between the two groups. The pre-malignant lesion detection rate in the trial vs control group was 65.6 % vs 44.2 % (OR 2.411; 95 % CI 1.608-3.614; p < 0.001), the polyp detection rate was 73.8 % vs 59.9 % (OR 1.889; 95 % CI 1.242-2.876; p = 0.003), the adenoma detection rate was 62.6 % vs 44.2 % (OR 2.110; 95 % CI 1.411-3.155; p < 0.001) and the sessile serrated lesion detection rate was 17 % vs 4.1 % (OR 4.816; 95 % CI 2.014-11.515; p < 0.001). The mean number of pre-malignant and sessile serrated lesions was 1.70 vs 1.06 (p = 0.002) and 0.32 vs 0.06 (p = 0.001) lesions per colonoscopy, respectively. There was no significant change in any of the study outcomes according to the multivariate analysis with each single potential confounder.Conclusions:
patients involved in colonoscopy trials may benefit from higher quality examinations, as shown by the higher detection rates. Institutions should consider supporting clinical research in colonoscopy as a simple means to improve colonoscopy quality and colorectal cancer prevention. (AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Colorectal Neoplasms
/
Adenoma
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Colonic Polyps
/
Colonoscopy
Limits:
Humans
Language:
English
Journal:
Rev. esp. enferm. dig
Year:
2022
Document type:
Article
Institution/Affiliation country:
Hospital Beatriz Ângelo/Portugal
/
Hospital do Divino Espirito Santo/Portugal
/
Instituto Português de Oncologia/Portugal
/
Professor Doutor Fernando Fonseca Hospital/Portugal