Relation of beclin-1 and bcl-2 expressions with pathological parameters and prognosis in clear cell renal cell carcinomas
Arch. esp. urol. (Ed. impr.)
; 75(4): 368-374, May 28, 2022. tab, graf
Article
in English
| IBECS
| ID: ibc-209218
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Introduction:
The most common type of renal cancers is the clear cell renal cell carcinoma (CCRCC) and 98% of CCRCCshave a loss of sequence in the short arm of chromosome 3 by deletion or translocation. Programmed cell death; another possiblemechanism of tumorigenesis, comprises two separate components apoptosis and autophagy. This study aims to show the relation between the prognostic parameters and survival, and Beclin-1, as the representative marker of autophagy, and Bcl-2 as therepresentative marker of apoptosis in CCRCC patients. In this study, we aimed to determine if Beclin-1 and Bcl-2 expressionlevels can provide any prognostic information about CCRCC patients.Methods:
We examined a total of 84 patients who underwent partial or radical nephrectomy and were diagnosed as havingCCRCC between January 2008 and December 2015. Immunohistochemical staining was performed, the evaluation was forBeclin-1 and Bcl-2 semi-quantitative, and based on the percentage of positively stained cells (proportion) and staining intensity.Results:
There was only a statistical significance between Beclin-1 expression and age (r-0.274; p=0.012; p <0.05). There wasa marginal significance between ISUP grade and Beclin-1 (p=0.051). The relation of Bcl-2 expression with the ISUP grade,recurrence, metastasis, and mortality revealed statistical significance (p=0.001, p=0.019, p=0.009, p=0.013, respectively). TheISUP grade and the Bcl-2 expression revealed statistical significance on multivariate analysis ( HR 7.453, 95% CI 1.935-28.713,p=0.004). The 5-year and 10-year tumor recurrences rates were lower in Bcl-2 positive group, and Bcl-2 positive group experienced longer disease free and overall survival...(AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Carcinoma, Renal Cell
/
Proto-Oncogene Proteins c-abl
/
Beclin-1
/
Kidney Neoplasms
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Arch. esp. urol. (Ed. impr.)
Year:
2022
Document type:
Article
Institution/Affiliation country:
Basaksehir Cam and Sakura City Hospital/Turkey
/
Istanbul Medeniyet University Göztepe Prof. Dr. Suleyman Yalcin City Hospital/Turkey
/
Malatya Research and Training Hospital/Turkey