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Prognostic and clinicopathological significance of tumor-stroma ratio in head and neck squamous cell carcinoma: A systematic review
Morais, Everton Freitas de; Morais, Hannah Gil de Farias; Martins, Hélder Domiciano Dantas; Carlan, Leonardo Magalhães; Costa, Antônio de Lisboa Lopes; Freitas, Roseana de Almeida.
Affiliation
  • Morais, Everton Freitas de; Federal University of Rio Grande do Norte. Natal. Brazil
  • Morais, Hannah Gil de Farias; Federal University of Rio Grande do Norte. Natal. Brazil
  • Martins, Hélder Domiciano Dantas; Federal University of Paraiba. João Pessoa. Brazil
  • Carlan, Leonardo Magalhães; Federal University of Rio Grande do Norte. Natal. Brazil
  • Costa, Antônio de Lisboa Lopes; Federal University of Rio Grande do Norte. Natal. Brazil
  • Freitas, Roseana de Almeida; Federal University of Rio Grande do Norte. Natal. Brazil
Med. oral patol. oral cir. bucal (Internet) ; 27(4): 1-9, July 2022. tab, graf, ilus
Article in English | IBECS | ID: ibc-209793
Responsible library: ES1.1
Localization: ES15.1 - BNCS
ABSTRACT

Background:

Analysis of the tumor microenvironment has been proposed as a strategy for the treatment and prognosis of different neoplastic processes. A grading system based on the tumor-stroma ratio (TSR), which evaluates theproportion of stroma in relation to neoplastic parenchyma at the invasion front, has shown a strong prognostic valuein different neoplastic processes. The aim of the present systematic review was to understand the role of the TSR inhead and neck squamous cell carcinoma (HNSCC), evaluating its correlation with clinical and prognostic parameters.Material and

Methods:

An electronic search was performed in PubMed/Medline, Web of Science, Science Direct,Scopus, Embase, and the Cochrane Collaboration Library. Publications assessing the relationship between TSRand prognosis in cases of HNSCC were eligible. The quality of the studies was assessed independently by fourevaluators using the Newcastle-Ottawa scale.

Results:

After application of the previously es+lished inclusion/exclusion criteria, nine articles were included inthe qualitative synthesis. With regards to quality on the Newcastle-Ottawa scale, an overall value of 4.55 was obtained. This systematic review demonstrated a strong association between TSR and prognosis in esophageal andoral squamous cell carcinomas.

Conclusions:

Histopathological analysis of the TSR can optimize the analysis of the prognosis of cases diagnosedwith HNSSC. In addition, the TSR is a reliable and simple parameter that can be evaluated in hematoxylin/eosinstained slides during routine laboratory examinations, showing high inter- and intraobserver agreement. (AU)
Subject(s)


Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Prognosis / Carcinoma, Squamous Cell / Stromal Cells / Tumor Microenvironment / Squamous Cell Carcinoma of Head and Neck / Head and Neck Neoplasms Limits: Humans Language: English Journal: Med. oral patol. oral cir. bucal (Internet) Year: 2022 Document type: Article Institution/Affiliation country: Federal University of Paraiba/Brazil / Federal University of Rio Grande do Norte/Brazil

Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Prognosis / Carcinoma, Squamous Cell / Stromal Cells / Tumor Microenvironment / Squamous Cell Carcinoma of Head and Neck / Head and Neck Neoplasms Limits: Humans Language: English Journal: Med. oral patol. oral cir. bucal (Internet) Year: 2022 Document type: Article Institution/Affiliation country: Federal University of Paraiba/Brazil / Federal University of Rio Grande do Norte/Brazil
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