Investigating the human rhinovirus co-infection in patients with asthma exacerbations and COVID-19
Pharm. pract. (Granada, Internet)
; 20(2): 1-10, Apr.-jun. 2022. tab, graf
Article
in English
| IBECS
| ID: ibc-210425
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Objective:
To investigate the co-infections with human rhinovirus (HRV) among patients with asthma exacerbation and COVID-19 in Jordan. Also, to determine the frequency of acute asthma exacerbation before and during the COVID-19 pandemic on a matched basis.Methods:
The data of this prospective cohort research consisted of clinical variables. During the first visit, and after 14-days, nasopharyngeal swabs were taken and the quantitative polymerase chain reaction was performed for HRV and SARS-CoV-2 detection.Results:
Forty-seven out of 175 (26.9%) COVID-19 adult cases have been diagnosed with asthma. The number of asthma exacerbations among the study participants was higher during 2021 than in 2020 (p=0.035). Most of the included asthmatic participants (61.7%) were only positive for SARS-CoV-2 and 38.3% were co-infected with HRV. The SARS-CoV-2 cycle threshold value was lower in samples infected with both viruses compared to samples infected with SARS-CoV-2 alone, p<0.005.Conclusion:
Our findings indicate that HRV and SARS-CoV-2 were significantly more prevalent in asthma exacerbations than stable asthma. Thus, HRV and/or SARS-CoV-2 infections were potentially cofactors or contributors to the asthma exacerbation in this cohort. This is the first study, in Jordan, to investigate the HRV co-infection in COVID-19 asthmatic patients and HRV could be related with a higher severity of COVID-19. (AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Asthma
/
Rhinovirus
/
Coronavirus Infections
/
Severe acute respiratory syndrome-related coronavirus
/
Pandemics
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Pharm. pract. (Granada, Internet)
Year:
2022
Document type:
Article
Institution/Affiliation country:
Applied Science Private University/Jordan
/
Northumbria University/UK
/
The University of Jordan/Jordan