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Resistance to beta-lactams in Gram-negative bacilli: relevance and potential therapeutic alternatives
Garcia-Bustos, Víctor; Cabañero-Navalón, Marta Dafne; Salavert Lletí, Miguel.
Affiliation
  • Garcia-Bustos, Víctor; University and Polytechnic Hospital La Fe. Clinical Medical Area. Unit of Infectious Diseases. Valencia. Spain
  • Cabañero-Navalón, Marta Dafne; University and Polytechnic Hospital La Fe. Clinical Medical Area. Unit of Infectious Diseases. Valencia. Spain
  • Salavert Lletí, Miguel; University and Polytechnic Hospital La Fe. Clinical Medical Area. Unit of Infectious Diseases. Valencia. Spain
Rev. esp. quimioter ; 35(supl. 2): 1-15, Sept. 2022. tab, ilus
Article in English | IBECS | ID: ibc-210688
Responsible library: ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
The indiscriminate and massive antibiotic use in the clinical practice and in agriculture or cattle during the past few decades has produced a serious world health problem that entails high morbidity and mortality the antibiotic multi-drug resistance. In 2017 and 2019, the World Health Organization published a list of urgent threats and priorities in the context of drug resistance, which only included Gram-negative bacteria and specially focused on carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa, as well as carbapenem and third generation cephalosporin-resistant Enterobacteriaceae. This scenario emphasizes the need of developing and testing new antibiotics from different families, such as new beta-lactams, highlighting cefiderocol and its original mechanism of action; new beta-lactamase inhibitors, with vaborbactam or relebactam among others; new quinolones such as delafloxacin, and also omadacycline or eravacycline, as members of the tetracycline family. The present work reviews the importance and impact of Gram-negative bacterial infections and their resistance mechanisms, and analyzes the current therapeutic paradigm as well as the role of new antibiotics with a promising future in the era of multi and pan-drug resistance. (AU)
Subject(s)


Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Gram-Negative Bacterial Infections / Beta-Lactam Resistance / Anti-Bacterial Agents Limits: Humans Language: English Journal: Rev. esp. quimioter Year: 2022 Document type: Article Institution/Affiliation country: University and Polytechnic Hospital La Fe/Spain

Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Gram-Negative Bacterial Infections / Beta-Lactam Resistance / Anti-Bacterial Agents Limits: Humans Language: English Journal: Rev. esp. quimioter Year: 2022 Document type: Article Institution/Affiliation country: University and Polytechnic Hospital La Fe/Spain
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