Analysis of response of severe eosinophilic asthmatic patients to benralizumab
Allergol. immunopatol
; 50(6): 163-168, 01 nov. 2022. tab
Article
in English
| IBECS
| ID: ibc-211527
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Introduction Clinical trials and real-life studies have been published showing effectiveness of benralizumab in severe eosinophilic asthmatic patients. The aim of the present study is to describe super-responders to benralizumab in a series of 79 patients who completed at least 1 year of treatment, and to compare super-responders with non super-responders. Methods This is a multicenter study of the Register of Severe Asthma of the Region of Murcia (RE-ASGRAMUR) Group performed in eight hospitals under the conditions of routine clinical practice. Patients with zero exacerbations and no oral corticosteroid therapy for asthma were considered super-responders. We analyzed clinical, functional, and inflammatory parameters of selected patients. Results In all, 50 of the 79 patients (63%) met the super-responder criteria. In addition, 36% of the patients (26/71) were considered as complete responders to treatment (super--responder + Asthma Control Test [ACT] ≥ 20 + forced expiratory volume in 1 s [FEV1] ≥ 80%). The super--responders were significantly older in age (P = 0.0029), had higher eosinophils count (P = 0.0423), higher proportion of nasal polyps (P = 0.036), and they had less severe disease at baseline. After 1 year of treatment, the super-responders had higher levels of ACT questionnaire (23 vs 19, P = 0.0007) and better percentage of FEV1 (83 vs 75, P = 0.0359). Conclusion Almost two of the three patients treated with benralizumab were super--responders after 1 year of treatment and 36% had a complete response. Super-responders were associated with older age, higher eosinophils count, had nasal polyposis as comorbidity, and had less severe disease at baseline. This data illustrated the good real-life response of patients with severe eosinophilic asthma to the treatment with benralizumab (AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Pulmonary Eosinophilia
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Asthma
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Nasal Polyps
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Anti-Asthmatic Agents
Limits:
Aged
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Female
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Humans
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Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2022
Document type:
Article
Institution/Affiliation country:
Hospital Rafael Méndez/Spain
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Hospital de la Vega Lorenzo Guirao/Spain
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University Clinic Hospital Virgen de la Arrixac/Spain
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University General Hospital Los Arcos/Spain
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University General Hospital Morales Meseguer/Spain
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University General Hospital Morales Meseguer,/Spain
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University General Hospital Reina Sofia/Spain
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University General Hospital Santa Lucia/Spain