MicroRNA-211-5p as a Biomarker in Early Detection of Uremic Vascular Calcification among Patients with End Stage Renal Disease
Arch. esp. urol. (Ed. impr.)
; 75(8): 714-719, 28 sept. 2022. tab, graf
Article
in English
| IBECS
| ID: ibc-212098
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Background:
Vascular calcification (VC) is a serious pathological manifestation of vascular terminals and is an important pathological basis of cardiovascular diseases in patients with end-stage renal disease (ESRD). This study explored the clinical value of serum microRNA-211-5p (miR-211-5p) in VC in patients with ESRD, this study was designed.Methods:
The relative expression of miR-211-5p in the serum of the calcified group and the non-calcified group was quantified by quantitative reverse transcription polymerase chain reaction. The clinical biochemical indexes and the expression differences in miR-211-5p expression in the serum of groups were compared by two independent samples t-test or nonparametric test or one-way analysis of variance test. The receiver operating characteristic (ROC), Kaplan-Meier, and Cox regression analysis were carried out to analyze the predictive value of serum miR-211-5p in patients with ESRD.Results:
The relative quantification of serum miR-211-5p was lessened in calcified group and gradually decreased with the progression of VC. Serum miR-211-5p had a high diagnostic accuracy in the diagnosis of VC progression in ESRD patients. Kaplan-Meier and Cox regression methods revealed that miR-211-5p might be an independent biomarker for prognosis of ESRD patientsConclusions:
MiR-211-5p is a potential diagnostic and prognostic marker of VC in patients with ESRD (AU)
Search on Google
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
MicroRNAs
/
Vascular Calcification
/
Kidney Failure, Chronic
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Arch. esp. urol. (Ed. impr.)
Year:
2022
Document type:
Article
Institution/Affiliation country:
Hubei University of Medicine/China