Twice daily low frequency rTMS for treatment-resistant auditory hallucinations
Int. j. clin. health psychol. (Internet)
; 23(1): 1-5, ene.-abr. 2023. ilus, tab, graf
Article
in En
| IBECS
| ID: ibc-213102
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Background: Repetitive transcranial magnetic stimulation (rTMS) has emerged as a therapeutic solution in patients with treatment-resistant auditory verbal hallucinations. However, the optimal stimulation parameters remain unclear, especially for patients with clozapine-resistant symptoms. Method: In an open label retrospective study, we investigated whether parameters of stimulation that were useful in patients with major depressive disorder would help schizophrenia patients with treatment-resistant auditory verbal hallucinations. Fourteen participants, including 9 under clozapine, received 30 sessions of 1 Hz rTMS over 3 weeks (360 pulses per sessions delivered with 60 s on and 30 s off at 110% of the resting motor threshold, 2 sessions per day). Stimulations were applied over the left temporoparietal junction (T3-P3 according to 10/20 system). Results: After rTMS, a significant decrease of auditory verbal hallucinations was observed (−38.7% ± 31.8, p = 0.003) on the Auditory Hallucination Rating Scale. The beneficial effects were also significant in the 9 patients who were also receiving clozapine (−34.9% ± 28.4, p = 0.01). Conclusions: Low frequency rTMS, 30 sessions over 3 weeks, appears to be a suitable approach to decrease treatment-resistant auditory verbal hallucinations, including in patients with clozapine-resistant symptoms. Results from the current retrospective study in the clinical settings need to be confirmed by large-scale randomized sham-controlled trials. (AU)
Key words
Full text:
1
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Schizophrenia
/
Transcranial Magnetic Stimulation
/
Hallucinations
Limits:
Adult
/
Female
/
Humans
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Male
Country/Region as subject:
Europa
Language:
En
Journal:
Int. j. clin. health psychol. (Internet)
Year:
2023
Document type:
Article