HLA-G in asthma and its potential as an effective therapeutic agent
Allergol. immunopatol
; 51(1): 22-29, ene. 2023. ilus
Article
in English
| IBECS
| ID: ibc-214036
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Objective:
Asthma is a heterogeneous disease. Severity of asthma and sensitivity to medications vary across asthma subtypes. Human leukocyte antigen (HLA)-G has a wide range of functions in normal and pathological physiology. Due to its powerful immune function, HLA-G participates in the pathogenesis of different asthma phenotypes by regulating the activity and function of various immune cells. The mechanism of HLA-G in asthma is not fully clear, and there is no consensus on its mechanism in asthma. Further studies are needed to explore the role of HLA-G in different phenotypes of human asthma.Methods:
Observational study.Results:
HLA-G is an important immunomodulatory factor in asthma. Studies have found different levels of HLA-G in patients with different asthma subtypes and healthy controls, but other studies have come to the opposite conclusion.Conclusion:
We speculate that further study on the mechanism of HLA-G in asthma pheno-types may explain some of the contradictions in current studies. Findings should provide information regarding the potential of HLA-G as a novel target for asthma diagnosis and treatment (AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Asthma
/
Immunomodulation
/
HLA-G Antigens
Limits:
Humans
Language:
English
Journal:
Allergol. immunopatol
Year:
2023
Document type:
Article
Institution/Affiliation country:
Jilin University Second Hospital/China