Antibodies to Der p 1 and Der p 2 in allergic patients
Allergol. immunopatol
; 49(2): 46-52, mar. 2021. tab, graf
Article
in English
| IBECS
| ID: ibc-214237
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Introduction and objectives Atopic individuals are characterized by increased IgE production and Th2 response if exposed to certain antigens. It is known that the mother transfers anti-mite antibodies to the fetus and newborn, IgG thru the placenta, and IgA thru breastfeeding, but it is not clear whether there is a protective mechanism mediated by them concerning the development of future allergies. This study aimed to compare the levels of IgA, IgG, and IgE antibodies specific to Der p 1 and Der p 2 between atopic and healthy individuals. Methods Serum samples of 98 patients and 44 healthy controls were subjected to quantification for specific IgE, IgG, and IgA antibodies against Der p 1 and Der p 2 by ImmunoCap® and ELISA, and subjected to statistical analysis as indicated. Results Atopic patients had higher serum levels of IgE, IgG, and IgA specific to Der p 1 and Der p 2. The correlation was more robust between IgE and IgG antibodies. Conclusions Allergic patients produce higher levels of antibodies against Der p 1 and Der p 2 compared with healthy individuals. The mechanisms involved still require detailed studies (AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Cysteine Endopeptidases
/
Dermatophagoides pteronyssinus
/
Antigens, Dermatophagoides
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Arthropod Proteins
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Hypersensitivity, Immediate
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2021
Document type:
Article
Institution/Affiliation country:
Universidade Federal de São Paulo/Brazil
/
Universidade de São Paulo/Brazil