Retinol-binding protein 4 and plasminogen activator inhibitor-1 as potential prognostic biomarkers of non-allergic asthma caused by obesity in adolescents
Allergol. immunopatol
; 49(3): 21-29, mayo 2021. tab, graf
Article
in English
| IBECS
| ID: ibc-214262
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Background:
Non-allergic asthma caused by obesity is a complication of the low-grade chronic inflammation inherent in obesity. Consequently, the serum concentrations of adipokines such as retinol-binding protein 4 (RBP4) and plasminogen activator inhibitor-1 (PAI-1) increase. No gold standard molecule for the prediction of non-allergic asthma among obese patients has been identified.Objective:
To evaluate RBP4 and PAI-1 as prognostic biomarkers of non-allergic asthma caused by obesity.Methods:
A cross-sectional study between four groups of adolescents (1) healthy (n = 35), (2) allergic asthma without obesity (n = 28), (3) obesity without asthma (n = 33), and (4) non-allergic asthma with obesity (n = 18).Results:
RBP4 was higher in the non-allergic asthma with obesity group than in the obesity without asthma group (39.2 ng/mL [95% confidence interval (CI) 23.876.0] vs. 23.5 ng/mL [95% CI 3.233.5], p < 0.01), and PAI-1 was higher in the non-allergic asthma with obesity group than in the obesity without asthma group (21.9 ng/mL [95% CI 15.726.5] vs. 15.9 ng/mL [95% CI 9.418.2], p < 0.05). Receiver operating characteristic (ROC) curve analysis demonstrated that the serum RBP4 cut-off value was >42.78 ng/mL, with an area under the ROC curve (AUC) of 0.741 (95% CI 0.5990.853, p = 0.001), considered acceptable. The PAI-1 cut-off value was >12.0 ng/mL, with an AUC of 0.699 (95% CI 0.5540.819, p = 0.008), considered fairConclusions:
RBP4 may be useful to predict non-allergic asthma among obese adolescents in clinical practice (AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Asthma
/
Retinol-Binding Proteins
/
Plasminogen Activator Inhibitor 1
/
Pediatric Obesity
Limits:
Adolescent
/
Child
/
Humans
Language:
English
Journal:
Allergol. immunopatol
Year:
2021
Document type:
Article
Institution/Affiliation country:
Hospital Infantil de Mexico Federico Gómez/Mexico
/
Hospital Infantil de México Federico Gómez/Mexico
/
Instituto Politécnico Nacional/Mexico
/
Instituto Politécnico Nacional/éxico
/
Universidad Nacional Autónoma de México/Mexico