Treatment with proton pump inhibitors as a cofactor in adverse reactions of patients undergoing oral food immunotherapy
Allergol. immunopatol
; 49(3): 169-172, mayo 2021. tab
Article
in English
| IBECS
| ID: ibc-214279
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Background and objectives Based on previous studies revealing acid-suppression medication as a risk factor for food allergy tolerance induction, we aimed to establish the importance of those findings in patients undergoing oral immunotherapy (OIT). Materials and methods, results We describe a case series of four patients who underwent milk OIT with a concomitant use of proton pump inhibitor (PPI) medication and who developed anaphylaxis after a known, previously tolerated dose of milk. Conclusions PPIs may act as a cofactor in patients undergoing OIT, triggering adverse reactions, irrespective of the PPI used or the dosage. It would be necessary to separate the administration of drug from food intake. Since OIT is a new form of treatment, long-term adverse events arising from PPI treatment and other possible triggers are still uncertain. Consequently, monitoring of patient must be prolonged over time. Additional investigations on the influence of different drugs in OIT maintenance phase are required (AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Desensitization, Immunologic
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Proton Pump Inhibitors
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Eosinophilic Esophagitis
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Food Hypersensitivity
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Gastritis
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Anaphylaxis
Limits:
Child
/
Female
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Humans
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Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2021
Document type:
Article
Institution/Affiliation country:
Gregorio Marañón University Hospital/Spain
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Severo Ochoa University Hospital/Spain