Laboratory screening test with inhalant and food allergens in atopic Brazilian children and adolescents: a performance
Allergol. immunopatol
; 49(5): 42-48, sept. 2021. tab, graf
Article
in English
| IBECS
| ID: ibc-214765
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
The Phadiatop Infant® (PhInf) is a panel developed to assess allergic sensitization (immunoglobulin E [IgE]) in children aged <5 years and combines inhalant and food allergens. The test has not been evaluated outside Europe. This is a cross-sectional study conducted at 11 pediatric allergy centers to evaluate PhInf as an allergic disease screening method in Brazilian children. Children as controls and patients (aged 6 months18 years) were grouped according to their primary disease and age group. PhInf and specific serum IgE (sIgE) screening was performed for Dermatophagoides pteronyssinus (DP), cat and dog epithelia, a mix of grasses and pollens, eggs, cows milk, peanuts, and shrimp. Values ≥ 0.35 kUA/L (or PAU/L) were considered positive. A total of 470 children and adolescents, which included 385 patients and 85 controls, participated in the study (47.7% boys, average age 6.3 years). In all, 72.6% of the participants had positive PhInf test (n = 341), with a higher proportion of those having food allergy (92.6%), atopic dermatitis (91.9%), and those aged >13 years having allergy (95%). The PhInf and sIgE agreement between patients (Kappa = 0.94, P < 0.001) and controls (Kappa = 0.84, P < 0.001) was high. PhInf and DP agreement in patients aged >13 years was excellent (Kappa = 0.936, P < 0.001). Compared with sIgE dosage, PhInf had high sensitivity (97%) and specificity (93%). Positivity of PhInf test in this population was high and had an excellent correlation with the allergens comprising the panel. It is a useful method for screening children suspected of having allergic diseases in a non-European country (AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Allergens
/
Hypersensitivity
Limits:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Country/Region as subject:
South America
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Brazil
Language:
English
Journal:
Allergol. immunopatol
Year:
2021
Document type:
Article
Institution/Affiliation country:
Albert Einstein Israeli Faculty of Health Sciences/Brazil
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Federal University Fronteira Sul/Brazil
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Federal University of Paraná/Brazil
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Federal University of Pernambuco/Brazil
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Federal University of Rio de Janeiro/Brazil
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Federal University of São Paulo, São Paulo/Brazil
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Nipo-Brazilian Hospital/Brazil