Pathophysiology of Chronic Bronchial Infection in Bronchiectasis
Arch. bronconeumol. (Ed. impr.)
; 59(2): 101-108, feb. 2023. tab, ilus
Article
in English
| IBECS
| ID: ibc-215581
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Bronchiectasis is a complex and heterogeneous disease. Its pathophysiology is poorly understood, but chronic bronchial infection plays an important role in its natural history, and is associated with poor quality of life, more exacerbations and increased mortality. Pseudomonas aeruginosa, Haemophilus influenzae and Staphylococcus aureus are the most common bacteria related to chronic bronchial infection. Non-tuberculous mycobacteria, fungi and respiratory viruses are also present during clinical stability, and may increase the risk of acute exacerbation. Chronic inflammation is present in bronchiectasis, especially neutrophilic inflammation. However, macrophages and eosinophils also play a key role in the disease. Finally, airway epithelium has innate mechanisms such as mucociliary clearance and antibacterial molecules like mucins and antimicrobial peptides that protect the airways from pathogens. This review addresses how the persistence of microorganisms in the airways and the imbalance of the immune system contribute to the development of chronic bronchial infection in bronchiectasis. (AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Quality of Life
/
Bronchiectasis
Limits:
Humans
Language:
English
Journal:
Arch. bronconeumol. (Ed. impr.)
Year:
2023
Document type:
Article
Institution/Affiliation country:
Hospital Clínic/Spain
/
Hospital La Fe/Spain
/
Hospital Sant Pau/Spain