A study on the antibacterial activity and antimicrobial resistance of pyridinium cationic pillar[5]arene against Staphylococcus aureus and Escherichia coli / Un estudio sobre la actividad antibacteriana y la resistencia antimicrobiana del pilar catiónico de piridinio[5]areno contra Staphylococcus aureus y Escherichia coli
Int. microbiol
; 26(1): 59-68, Ene. 2023. graf
Article
in English
| IBECS
| ID: ibc-215917
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
An increasing number of infections caused by multidrug-resistant (MDR) Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) have severely affected human society. Thus, it is essential to develop an alternative type of antibacterial agents that has a different bacterial resistance mechanism from that of traditional antibiotics. After the synthesis and structural characterization of a cationic pillar[5]arene with pyridinium groups (PP5), the antibacterial and antibiofilm activities as well as its microbial resistance were systematically investigated. In-depth evaluation of biological studies revealed that PP5 was an active antibacterial agent, with surprising antibiofilm formation ability against E. coli and S. aureus. From the results of differential scanning calorimetry and transmission electron microscopy, it was concluded that the microbicidal activity of PP5 was due to the physical disruption of the pathogens membrane and the subsequent leakage of cytoplasmic components, which could greatly reduce the rapid generation of resistance. It was presented that the easily available PP5 has high activity to inhibit Gram-positive and Gram-negative bacteria and/or their biofilms with low cytotoxicity. This pillar[5]arene derivative can be used as a good candidate for controlling drug-resistant pathogenic bacterial infections and treating MDR bacteria.(AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Staphylococcus aureus
/
Calorimetry
/
Microscopy, Electron
/
Biofilms
/
Drug Resistance, Bacterial
/
Escherichia coli
/
Anti-Bacterial Agents
Limits:
Humans
Language:
English
Journal:
Int. microbiol
Year:
2023
Document type:
Article
Institution/Affiliation country:
Hangzhou Normal University/Peoples Republic of China
/
Zhejiang Gongshang University/Peoples Republic of China