Meningeal carcinomatosis as the initial manifestation of lymphoma / Carcinomatosis meníngea como manifestación inicial de linfoma
J. negat. no posit. results
; 7(4): 322-327, Oct-Dic. 2022. tab, ilus
Article
in English
| IBECS
| ID: ibc-216535
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Introduction:
Leptomeningeal carcinomatosis (LC) is diagnosed in 4-15% of cancer patients, and most cases (70%) are in the advanced phase of the disease. In only 5-10% of patients with LC, it is the initial manifestation of cancer.Case report We present a case of a 46-year-old man with leptomeningeal carcinomatosis as the first manifestation of type B high-grade lymphoma. Cerebrospinal fluid (CSF) showed pleocytosis with a predominance of mononuclear cells, hyperproteinorrhachia, and glucose consumption. CSF cytology was negative for malignant cells in two samples. Magnetic resonance imaging and CSF flow cytometry gave the diagnosis.Discussion:
LC is a diagnostic challenge. Differential diagnosis arises with infectious processes (tuberculosis) and autoimmune diseases. In cerebrospinal fluid, flow cytometry (FCM) has a higher sensitivity than cytology for the diagnosis of LC.(AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Physical Examination
/
Cerebrospinal Fluid
/
Meningeal Carcinomatosis
/
Flow Cytometry
/
Inpatients
Limits:
Humans
/
Male
Language:
English
Journal:
J. negat. no posit. results
Year:
2022
Document type:
Article
Institution/Affiliation country:
Albacete University Hospital Complex/Spain
/
Hospital Infanta Cristina/Spain
/
Hospital de Villarrobledo/Spain