Comparison of inflammation markers and severity of illness among patients with COVID-19, acute psychiatric disorders and comorbidity
Eur. j. psychiatry
; 37(2): 125-132, abril-junio 2023. tab
Article
in English
| IBECS
| ID: ibc-219647
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Background and objectives:
Neutrophil, lymphocyte counts, lactate dehydrogenase (LDH), D-dimer, fibrinogen, and comorbid illness are associated with the course and prognosis of COVID-19. However, the course of acute severe psychiatric disorders overlapping with COVID-19 infection was not investigated and remained as an unclarified research area. This study aimed to demonstrate inflammatory markers and the course of patients suffering from both conditions.MethodsThirty-eight inpatients with COVID-19 and comorbid acute psychiatric disorders (COVID-19+PD), 31 inpatients with COVID-19, and 38 inpatients with an acute psychiatric disorder (PD) were included in the study. Neutrophil, lymphocyte counts, serum ferritin, lactate dehydrogenase (LDH), D-dimer, fibrinogen, Systemic immune-inflammation index (SII), neutrophil/lymphocyte ratio (NLR), and C-reactive protein (CRP) were compared to evaluate inflammation levels.ResultsPatients with SARS-CoV-2 infection had older age compared to the PD group. CALL (Comorbidity, age, lymphocyte, lactate dehydrogenase) scores which predict the progression risk in patients with COVID-19 pneumonia, of both COVID-19 groups were found similar. The COVID-19+PD had higher SII in the study sample. Additionally, the COVID-19+PD group had higher NLR, ferritin, and CRP levels than those of the PD group.ConclusionsThe prognosis of COVID-19 is not worse when accompanied by a psychiatric disorder. Laboratory assessment can guide clinicians to distinguish those infected with SARS-CoV-2 within psychiatric inpatient units. The biochemical assessment did not robustly support higher inflammatory levels in the comorbid COVID-19 and psychiatric disorder group compared to the COVID-19 group. (AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Psychotropic Drugs
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Comorbidity
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Coronavirus Infections
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Severe acute respiratory syndrome-related coronavirus
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Inflammation
Limits:
Humans
Language:
English
Journal:
Eur. j. psychiatry
Year:
2023
Document type:
Article
Institution/Affiliation country:
İstanbul Ayvansaray University/Turkey
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Diyarbakır Childrens' Hospital/Turkey
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Istanbul Bakirkoy Prof Dr. Mazhar Osman Ruh Mental and Nervous Diseases Training and Research Hospital/Turkey
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Kanuni Sultan Süleyman Training and Research Hospital/Turkey