Efavirenz as a potential drug for the treatment of triple-negative breast cancers
Clin. transl. oncol. (Print)
; 23(2): 353-363, feb. 2021.
Article
in English
| IBECS
| ID: ibc-220620
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Purpose In contrast to hormone receptor driven breast cancer, patients presenting with triple-negative breast cancer (TNBC) often have limited drug treatment options. Efavirenz, a non-nucleoside reverse transcriptase (RT) inhibitor targets abnormally overexpressed long interspersed nuclear element 1 (LINE-1) RT and has been shown to be a promising anticancer agent for treating prostate and pancreatic cancers. However, its effectiveness in treating patients with TNBC has not been comprehensively examined. Methods In this study, the effect of Efavirenz on several TNBC cell lines was investigated by examining several cellular characteristics including viability, cell division and death, changes in cell morphology as well as the expression of LINE-1. Results The results show that in a range of TNBC cell lines, Efavirenz causes cell death, retards cell proliferation and changes cell morphology to an epithelial-like phenotype. In addition, it is the first time that a whole-genome RNA sequence analysis has identified the fatty acid metabolism pathway as a key regulator in this Efavirenz-induced anticancer process. Conclusion In summary, we propose Efavirenz is a potential anti-TNBC drug and that its mode of action can be linked to the fatty acid metabolism pathway (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Reverse Transcriptase Inhibitors
/
Cyclopropanes
/
Benzoxazines
/
Triple Negative Breast Neoplasms
/
Antineoplastic Agents
Limits:
Female
/
Humans
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2021
Document type:
Article
Institution/Affiliation country:
The Australian National University/Australia